2. Gene
  3. Phgdh - phosphoglycerate dehydrogenase Gene

Phgdh - phosphoglycerate dehydrogenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 58835 | Gene type: protein coding

About Phgdh

Primary_assembly 2: 185,906,966-185,935,944 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 213 orthologues, 7 paralogues and is associated with 11 phenotypes. Biased expression in Kidney (RPKM 314.9), Thymus (RPKM 211.1) and 9 other tissues.

Summary

Enables phosphoglycerate dehydrogenase activity. Predicted to be involved in serine family amino acid biosynthetic process. Predicted to act upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Phgdh Products(1)

mRNA Protein Name
NM_031620.2 NP_113808.1 D-3-phosphoglycerate dehydrogenase
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables phosphoglycerate dehydrogenase activity IDA
IDA: Inferred from direct assay
9163325 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Phgdh Protein Structure

PGDH_4

PGDH_4: cd12173 (7 - 309)

PGDH_inter

PGDH_inter: cl44735 (329 - 406)

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  • 533 a.a.
Protein Preferred Names Protein Names

D-3-phosphoglycerate dehydrogenase

3-PGDH

3-phosphoglycerate dehydrogenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101966 NCT-503 99.85% Unkown
HY-100012 CBR-5884 99.02% Unkown
HY-141412 D-(-)-3-Phosphoglyceric acid disodium Inhibitor ≥98.0% Unkown
HY-117240 NCT-502 99.72% Unkown
HY-126253 BI-4916 98.55% Unkown
HY-123269 PKUMDL-WQ-2101 Inhibitor 99.94% Unkown
HY-126254 BI-4924 99.55% Unkown
HY-148570 PHGDH-IN-3 Inhibitor 98.99% Unkown
HY-121733 PHGDH-inactive 99.93% Unkown
HY-123418 PKUMDL-WQ-2201 Inhibitor 98.72% Unkown
HY-RS10433 Phgdh Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-145860 PHGDH-IN-2 / Unkown
HY-RS10432 PHGDH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10434 Phgdh Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-125273 DNS-pE / Unkown
HY-160252 PHGDH-IN-4 Inhibitor / Unkown
HY-161456 PHGDH-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phgdh NCBI NCBI:26227