2. Metabolic Enzyme/Protease
  3. Phosphoglycerate Dehydrogenase (PHGDH)
  4. PKUMDL-WQ-2201

PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor (IC50=35.7 μM). PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth.

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PKUMDL-WQ-2201 Chemical Structure

PKUMDL-WQ-2201 Chemical Structure

CAS No. : 592474-91-4

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Based on 1 publication(s) in Google Scholar

PKUMDL-WQ-2201 Related Antibodies

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  • Purity & Documentation

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Description

PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor (IC50=35.7 μM). PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth[1][2].

IC50 & Target

IC50: 35.7 μM (PHGDH WT), 69 μM (PHGDH T59A), >300 μM (PHGDH T56AK57A)[1]
In Vitro

PKUMDL-WQ-2201 (10 nM-100 μM; 3 d) shows good selectivity for PHGDH-amplified breast cancer cell lines, inhibits cell viability with EC50s of 7.7 μM (MDA-MB-468) and 10.8 μM (HCC70), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PKUMDL-WQ-2201 Related Antibodies
In Vivo

PKUMDL-WQ-2201 (5-20 mg/kg; i.p.; once daily for 30 d) exhibits substantial inhibitory effects on MDA-MB-468 xenografts compared with vehicle-treated mice, without affecting the tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

351.81

Formula

C15H14ClN3O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(C=C1Cl)C2=CC=C(O2)/C=N/NC(NCC)=S)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (284.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8424 mL 14.2122 mL 28.4244 mL
5 mM 0.5685 mL 2.8424 mL 5.6849 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8424 mL 14.2122 mL 28.4244 mL 71.0611 mL
5 mM 0.5685 mL 2.8424 mL 5.6849 mL 14.2122 mL
10 mM 0.2842 mL 1.4212 mL 2.8424 mL 7.1061 mL
15 mM 0.1895 mL 0.9475 mL 1.8950 mL 4.7374 mL
20 mM 0.1421 mL 0.7106 mL 1.4212 mL 3.5531 mL
25 mM 0.1137 mL 0.5685 mL 1.1370 mL 2.8424 mL
30 mM 0.0947 mL 0.4737 mL 0.9475 mL 2.3687 mL
40 mM 0.0711 mL 0.3553 mL 0.7106 mL 1.7765 mL
50 mM 0.0568 mL 0.2842 mL 0.5685 mL 1.4212 mL
60 mM 0.0474 mL 0.2369 mL 0.4737 mL 1.1844 mL
80 mM 0.0355 mL 0.1777 mL 0.3553 mL 0.8883 mL
100 mM 0.0284 mL 0.1421 mL 0.2842 mL 0.7106 mL
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PKUMDL-WQ-2201 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKUMDL-WQ-2201592474-91-4Phosphoglycerate Dehydrogenase (PHGDH)Inhibitorinhibitorinhibit

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