D-(-)-3-Phosphoglyceric acid disodium (Synonyms: 3-Phospho-D-glyceric acid disodium)

Cat. No.: HY-141412: FAQs
Data Sheet SDS COA Handling Instructions

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D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase (enolase). D-(-)-3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase (PHGDH) to modulate p53 protein and apoptosis.

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D-(-)-3-Phosphoglyceric acid disodium Chemical Structure

CAS No. : 80731-10-8

Size	Price	Stock
5 mg	USD 80	Ask For Quote & Lead Time
10 mg	USD 130	Ask For Quote & Lead Time
25 mg	USD 260	Ask For Quote & Lead Time
50 mg	USD 410	Ask For Quote & Lead Time
100 mg	USD 650	Ask For Quote & Lead Time

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Purity & Documentation
References
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Description

In Vitro

D-(-)-3-Phosphoglyceric acid disodium (low level) induces phosphorylation at the Ser46 site of p53^[1].
D-(-)-3-Phosphoglyceric acid disodium (high level) binding PHGDH mutants (R135W and V261M) impair p53 activation^[1].
D-(-)-3-Phosphoglyceric acid disodium (high level) binding to the PHGDH-R135W and PHGDH-V261M mutants blocks apoptosis induced by 8 hours of glucose starvation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

230.02

Formula

C₃H₅Na₂O₇P

CAS No.

80731-10-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@H](O)COP(O)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (434.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3474 mL	21.7372 mL	43.4745 mL
5 mM	0.8695 mL	4.3474 mL	8.6949 mL
10 mM	0.4347 mL	2.1737 mL	4.3474 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (557 KB)

COA (248 KB) HNMR (237 KB) CNMR (261 KB) MS (81 KB)

Handling Instructions (2659 KB)

References

[1]. Yu-Qing Wu, et al. Low glucose metabolite 3-phosphoglycerate switches PHGDH. Cell Res. 2023 Nov;33(11):835-850. [Content Brief]

[2]. Ramos ML, Justino LL, Gil VM, Burrows HD. NMR and DFT studies of the complexation of W(VI) and Mo(VI) with 3-phospho-D-glyceric and 2-phospho-D-glyceric acids. Dalton Trans. 2009;(43):9616-9624. [Content Brief]

[3]. Faller LD, et al. Calorimetric studies of the role of magnesium ions in yeast enolase catalysis. Proc Natl Acad Sci U S A. 1974;71(4):1083-1087. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.3474 mL	21.7372 mL	43.4745 mL	108.6862 mL
	5 mM	0.8695 mL	4.3474 mL	8.6949 mL	21.7372 mL
	10 mM	0.4347 mL	2.1737 mL	4.3474 mL	10.8686 mL
	15 mM	0.2898 mL	1.4491 mL	2.8983 mL	7.2457 mL
	20 mM	0.2174 mL	1.0869 mL	2.1737 mL	5.4343 mL
	25 mM	0.1739 mL	0.8695 mL	1.7390 mL	4.3474 mL
	30 mM	0.1449 mL	0.7246 mL	1.4491 mL	3.6229 mL
	40 mM	0.1087 mL	0.5434 mL	1.0869 mL	2.7172 mL
	50 mM	0.0869 mL	0.4347 mL	0.8695 mL	2.1737 mL
	60 mM	0.0725 mL	0.3623 mL	0.7246 mL	1.8114 mL
	80 mM	0.0543 mL	0.2717 mL	0.5434 mL	1.3586 mL
	100 mM	0.0435 mL	0.2174 mL	0.4347 mL	1.0869 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

D-(-)-3-Phosphoglyceric acid disodium Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-(-)-3-Phosphoglyceric acid disodium80731-10-83-Phospho-D-glyceric acid disodiumEnolasePhosphoglycerate Dehydrogenase (PHGDH)MDM-2/p53ApoptosisPhosphopyruvate hydrataseglycolysisintermediateyeast enolaseInhibitorinhibitorinhibit

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