Grb14 - growth factor receptor bound protein 14 Gene

Rattus norvegicus

Gene ID: 58844 | Gene type: protein coding

About Grb14

Summary

Enables phosphoprotein binding activity. Involved in several processes, including Insulin Receptor signaling pathway; negative regulation of Insulin Receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Located in Golgi apparatus; endosome; and plasma membrane. Orthologous to human GRB14 (growth factor receptor bound protein 14). [provided by Alliance of Genome Resources, Apr 2022]

Grb14 Products(1)

mRNA	Protein	Name
NM_031623.2	NP_113811.2	growth factor receptor-bound protein 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	9748281	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20932831	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	14623073	RGD
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	9748281	RGD
involved in intracellular signal transduction	IEP IEP: Inferred from expression pattern	9748281	RGD
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	9748281	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18657188	RGD
involved in negative regulation of meiotic cell cycle process involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	14623073	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	18657188	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth factor receptor-bound protein 14

GRB14 adapter protein

Grb14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Grb14	O88900	FGFR1	Homo sapiens	P11362	BRET	20932831
Cross	Grb14	O88900	FGFR1	Homo sapiens	P11362	Anti Tag CoIP	20932831

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05779	GRB14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grb14	NCBI	NCBI:2888

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