Dlg3 - discs large MAGUK scaffold protein 3 Gene

Rattus norvegicus

Also known as Dlgh3

Gene ID: 58948 | Gene type: protein coding

About Dlg3

Summary

Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and protein C-terminus binding activity. A structural constituent of postsynaptic density. Involved in positive regulation of protein tyrosine kinase activity. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Dlg3 Products(1)

mRNA	Protein	Name
NM_031639.2	NP_113827.1	disks large homolog 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15024025	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	16540568	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8702950	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	9115257	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	20410104	RGD
enables structural constituent of postsynaptic density	IDA IDA: Inferred from direct assay	20357126	RGD
enables structural constituent of postsynaptic density	IMP IMP: Inferred from mutant phenotype	20357126	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic shaft	IDA IDA: Inferred from direct assay	12738960	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20357126	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20357126	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12738960	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12738960	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	12738960	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	20357126	RGD
located in synapse	IDA IDA: Inferred from direct assay	12738960	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disks large homolog 3

PSD-95/SAP90-related protein 1	SAP-102
SAP102	discs, large homolog 3
synapse-associated protein 102

Dlg3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Dlg3	Q62936	GRIN2D	Homo sapiens	O15399	ELISA	11937501
Cross	Dlg3	Q62936	GRIN2B	Homo sapiens	Q13224	ELISA	11937501
Cross	Dlg3	Q62936	GRIN2B	Homo sapiens	Q13224	FPS	11937501
Intra	Dlg3	Q62936	Grin2b	Rattus norvegicus	Q00960	Filter Binding	8780649
Intra	Dlg3	Q62936	Grin2b	Rattus norvegicus	Q00960	ELISA	8780649
Cross	Dlg3	Q62936	GRIN2A	Homo sapiens	Q12879	ELISA	11937501
Cross	Dlg3	Q62936	GRIN2C	Homo sapiens	Q14957	ELISA	11937501
Cross	Dlg3	Q62936	GRIN2C	Homo sapiens	Q14957	FPS	11937501
Cross	Dlg3	Q62936	GRIN1	Homo sapiens	Q05586-2	FPS	11937501
Cross	Dlg3	Q62936	KCNA1	Homo sapiens	Q09470	ELISA	11937501
Intra	Dlg3	Q62936	Dgkz	Rattus norvegicus	O08560	Y2H	19229292
Intra	Dlg3	Q62936	Lrfn2	Rattus norvegicus	Q460M5	Anti Bait CoIP	16495444
Cross	Dlg3	Q62936	CRIPT	Homo sapiens	Q9P021	ELISA	11937501

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03798	DLG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlg3	NCBI	NCBI:1741

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