Carm1 - coactivator-associated arginine methyltransferase 1 Gene

Mus musculus

Also known as Prmt4; m9Bei

Gene ID: 59035 | Gene type: protein coding

About Carm1

Chromosome 9: 21,458,190-21,503,919 forward strand.GRCm39:CM001002.3

This gene has 10 transcripts (splice variants), 218 orthologues, 7 paralogues and is associated with 14 phenotypes. Ubiquitous expression in testis adult (RPKM 59.4), limb E14.5 (RPKM 52.7) and 28 other tissues.

Summary

Enables several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including histone H3-R17 methylation; positive regulation of fat cell differentiation; and regulation of intracellular Estrogen Receptor signaling pathway. Acts upstream of or within several processes, including intracellular Estrogen Receptor signaling pathway; regulation of growth plate cartilage chondrocyte proliferation; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; gonad; limb bud; and sensory organ. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Carm1 Products(3)

mRNA	Protein	Name
NM_021531.6	NP_067506.2	histone-arginine methyltransferase CARM1 isoform 1
NM_153141.1	NP_694781.1	histone-arginine methyltransferase CARM1 isoform 2
NM_001411233.1	NP_001398162.1	histone-arginine methyltransferase CARM1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3R17 methyltransferase activity	IDA IDA: Inferred from direct assay	11341840	MGI
enables histone H3R2 methyltransferase activity	IDA IDA: Inferred from direct assay	17882261	MGI
enables histone H3R26 methyltransferase activity	IDA IDA: Inferred from direct assay	17882261	MGI
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	10381882	MGI
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	17882261	MGI
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	19843527	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10381882	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19843527	MGI
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	10381882	MGI
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	19843527	MGI
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	11341840	MGI
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	18188184	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	10381882	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	15616592	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19725955	MGI
acts upstream of or within endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	19725955	MGI
acts upstream of or within estrogen receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12756295	MGI
acts upstream of or within negative regulation of protein binding	IDA IDA: Inferred from direct assay	19725955	MGI
involved in nuclear receptor-mediated steroid hormone signaling pathway	IDA IDA: Inferred from direct assay	14690606	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	15616592	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19725955	MGI
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	18188184	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15616592	MGI
acts upstream of or within protein localization to chromatin	IMP IMP: Inferred from mutant phenotype	15616592	MGI
acts upstream of or within protein methylation	IMP IMP: Inferred from mutant phenotype	12756295	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10381882	MGI
acts upstream of or within regulation of growth plate cartilage chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	19725955	MGI
involved in regulation of intracellular estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	19843527	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	22977234	MGI
located in cytosol	IDA IDA: Inferred from direct assay	19843527	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19843527	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	15616592	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Carm1 Protein Structure

CARM1

SmtA

AdoMet_MTases

0
100
200
300
400
500
608 a.a.

Protein Preferred Names

Protein Names

histone-arginine methyltransferase CARM1

protein arginine N-methyltransferase 4

protein arginine methyltransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114965	TP-064	Inhibitor	99.61%	Unkown
HY-111109	EZM 2302	Inhibitor	99.59%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-100565	SGC2085	Inhibitor	99.46%	Unkown
HY-12759	CARM1-IN-1	Inhibitor	≥95.0%	Unkown
HY-15214	CARM1-IN-3	Inhibitor	98.90%	Unkown
HY-15214A	CARM1-IN-3 dihydrochloride	Inhibitor	98.77%	Unkown
HY-156152A	CARM1 degrader-1 hydrochloride	Degrader	/	Unkown
HY-12759A	CARM1-IN-1 hydrochloride	Inhibitor	95.13%	Unkown
HY-157388	CARM1/HDAC2-IN-1	Inhibitor	95.17%	Unkown
HY-100855	DC_C66	Inhibitor	/	Unkown
HY-100565A	SGC2085 hydrochloride	Inhibitor	/	Unkown
HY-110137A	Furamidine	Inhibitor	/	Unkown
HY-136809	PRMT6-IN-2	Inhibitor	/	Unkown
HY-156152	CARM1 degrader-1	Inhibitor	/	Unkown
HY-156153	CARM1 degrader-2	Inhibitor	/	Unkown
HY-158157	ZL-28-6	Inhibitor	/	Unkown
HY-158158	CARM1-IN-5	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4		/	Unkown
HY-163561	CARM1-IN-6	Inhibitor	/	Unkown
HY-172368	PROTAC CARM1/IKZF3 degrader-1		/	Unkown
HY-RS01926	CARM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01927	Carm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01928	Carm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114206	SKI-73		/	Unkown
HY-117927	EPZ0025654	Inhibitor	/	Unkown
HY-172369	CARM1/IKZF3 ligand 1	Inhibitor	/	Unkown
HY-172370	Thalidomide-NH-C4-Boc		/	Unkown
HY-W013500	(1-Nitroethene-1,2-diyl)dibenzene	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Carm1	NCBI	NCBI:10498

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