2. Gene
  3. RANGAP1 - Ran GTPase activating protein 1 Gene

RANGAP1 - Ran GTPase activating protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SD; Fug1; RANGAP

Gene ID: 5905 | Gene type: protein coding

About RANGAP1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,244,779-41,302,369 (from NCBI)

This gene has 8 transcripts (splice variants) and 282 orthologues. Broad expression in testis (RPKM 19.7), skin (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RANGAP1 Products(3)

mRNA Protein Name
NM_001278651.2 NP_001265580.1 ran GTPase-activating protein 1
NM_001317930.2 NP_001304859.1 ran GTPase-activating protein 1
NM_002883.4 NP_002874.1 ran GTPase-activating protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
16428860 GOA
enables RNA binding IDA
IDA: Inferred from direct assay
26308891 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14729961 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
16428860 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
16428860 GOA
involved in negative regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
16449645 GOA
involved in nuclear export EXP
EXP: Inferred from Experiment
27160050 GOA
involved in protein sumoylation IDA
IDA: Inferred from direct assay
22194619 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SUMO ligase complex IPI
IPI: Inferred from physical interaction
22194619 GOA
colocalizes with kinetochore IDA
IDA: Inferred from direct assay
17363900 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
25468996 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
26308891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANGAP1 Protein Structure

LRR_6

LRR_6: Leucine Rich repeat (113 - 132)

LRR_6

LRR_6: Leucine Rich repeat (236 - 257)

LRR_6

LRR_6: Leucine Rich repeat (292 - 312)

LRR_6

LRR_6: Leucine Rich repeat (323 - 342)

RanGAP1_C

RanGAP1_C: RanGAP1 C-terminal domain (404 - 586)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 587 a.a.
Protein Preferred Names Protein Names

ran GTPase-activating protein 1

segregation distorter homolog

RANGAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Bait CoIP
23395904
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
22194619
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Tag CoIP
17036045
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Anti Bait CoIP
17000644
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
ITC
17099698
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
17099698
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Comigration in SDS
20414307
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
Comigration in SDS
16732283
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
X-Ray Diffraction
17099700
Intra RANGAP1 P46060 SUMO1 Homo sapiens P63165
GMS
17099700
Intra RANGAP1 P46060 UBE2I Homo sapiens P63279
Pull Down
23395904
Intra RANGAP1 P46060 UBE2I Homo sapiens P63279
X-Ray Diffraction
22194619
Intra RANGAP1 P46060 UBE2I Homo sapiens P63279
Y2H
21988832
Intra RANGAP1 P46060 RANBP2 Homo sapiens P49792
X-Ray Diffraction
22194619
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7

PARK7

Parkinson'S Disease 7

Autosomal Recessive Early-Onset Parkinson'S Disease 7

Parkinson Disease 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2

Autosomal Recessive Early-Onset Parkinson Disease Type 7

Parkinson Disease, Type 7
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11650 RANGAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RANGAP1 VGNC VGNC:76656
Felis catus RANGAP1 VGNC VGNC:69235
Mus musculus RANGAP1 MGD MGI:103071
Canis familiaris RANGAP1 VGNC VGNC:45340
Bos taurus RANGAP1 VGNC VGNC:33713
Rattus norvegicus RANGAP1 RGD RGD:1310380
Others RANGAP1 NCBI