RAP1B - RAP1B, member of RAS oncogene family Gene

Homo sapiens

Also known as K-REV; RAL1B

Gene ID: 5908 | Gene type: protein coding

About RAP1B

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,610,899-68,671,901 (from NCBI)

This gene has 33 transcripts (splice variants), 190 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 83.8), appendix (RPKM 79.8) and 25 other tissues.

Summary

This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

RAP1B Products(6)

mRNA	Protein	Name
NM_001010942.3	NP_001010942.1	ras-related protein Rap-1b isoform 1 precursor
NM_001251917.2	NP_001238846.1	ras-related protein Rap-1b isoform 2
NM_001251918.2	NP_001238847.1	ras-related protein Rap-1b isoform 2
NM_001251921.2	NP_001238850.1	ras-related protein Rap-1b isoform 3
NM_001251922.2	NP_001238851.1	ras-related protein Rap-1b isoform 4
NM_015646.6	NP_056461.1	ras-related protein Rap-1b isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	18309292	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	18309292	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	18309292	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16452984	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	23209302	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Rap protein signal transduction	IMP IMP: Inferred from mutant phenotype	21840392	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	21840392	GOA
involved in establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	21840392	GOA
NOT involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in positive regulation of integrin activation	IMP IMP: Inferred from mutant phenotype	19461049	GOA
involved in regulation of cell junction assembly	IMP IMP: Inferred from mutant phenotype	21840392	GOA
involved in regulation of establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	20332120	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	20332120	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18582561	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	14741744	GOA
NOT located in membrane raft	IDA IDA: Inferred from direct assay	18582561	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1B Protein Structure

Ras

0
100
184 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rap-1b

GTP-binding protein smg p21B

RAP1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAP1B	P61224	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	RAP1B	P61224	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	RAP1B	P61224	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	RAP1B	P61224	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	RAP1B	P61224	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	RAP1B	P61224	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	RAP1B	P61224	RALGDS	Homo sapiens	Q12967-6	Validated Y2H	32296183
Intra	RAP1B	P61224	RASSF5	Homo sapiens	Q8WWW0	Y2H Prey Pooling	25416956
Intra	RAP1B	P61224	RASSF5	Homo sapiens	Q8WWW0	Validated Y2H	25416956
Intra	RAP1B	P61224	RASSF5	Homo sapiens	Q8WWW0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

RAP1B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82079	RAP1 Antibody (YA1824)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cervical Non-Keratinizing Squamous Cell Carcinoma

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Babesiosis

Babesiasis	Infection By Babesia
Piroplasmosis	Human Babesiosis
Babesia Parasite Infection	Piroplasma Infection

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11653	RAP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAP1B	RGD	RGD:620577
Mus musculus	RAP1B	MGD	MGI:894315
Canis familiaris	RAP1B	VGNC	VGNC:108214

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