RASSF5 - Ras association domain family member 5 Gene

Homo sapiens

Also known as RAPL; Maxp1; NORE1; NORE1A; NORE1B; RASSF3

Gene ID: 83593 | Gene type: protein coding

About RASSF5

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,507,531-206,589,448 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 5 paralogues. Broad expression in bone marrow (RPKM 44.1), lymph node (RPKM 34.6) and 20 other tissues.

Summary

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several Other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RASSF5 Products(3)

mRNA	Protein	Name
NM_182663.4	NP_872604.1	ras association domain-containing protein 5 isoform A
NM_182664.4	NP_872605.1	ras association domain-containing protein 5 isoform B
NM_182665.4	NP_872606.1	ras association domain-containing protein 5 isoform C

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17517604	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9488663	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASSF5 Protein Structure

C1_1

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

ras association domain-containing protein 5

Rap1-binding protein

RASSF5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RASSF5	Q8WWW0	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	a8k940_human	Homo sapiens	A8K940	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	a8k940_human	Homo sapiens	A8K940	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	VPS28	Homo sapiens	Q548N1	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	RASSF5	Q8WWW0	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	BTRC	Homo sapiens	Q9Y297	Y2H Array	31515488
Intra	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Y2H Array	31515488
Intra	RASSF5	Q8WWW0	SMAD4	Homo sapiens	Q13485	Y2H	25502805
Intra	RASSF5	Q8WWW0	HRAS	Homo sapiens	P01112	Anti Bait CoIP	9488663
Intra	RASSF5	Q8WWW0	HRAS	Homo sapiens	P01112	Anti Tag CoIP	18596699
Intra	RASSF5	Q8WWW0	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	CoIP	15109305
Intra	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	Anti Tag CoIP	20562859
Intra	RASSF5	Q8WWW0	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
Intra	RASSF5	Q8WWW0	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	RASSF5	Q8WWW0	MYLIP	Homo sapiens	Q8WY64	Y2H Array	31515488
Intra	RASSF5	Q8WWW0	MYLIP	Homo sapiens	Q8WY64	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	RASSF5	Q8WWW0	RABIF	Homo sapiens	P47224	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	RABIF	Homo sapiens	P47224	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	RASSF5	Q8WWW0	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	RASSF5	Q8WWW0	RAP2B	Homo sapiens	P61225	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Validated Y2H	25416956
Intra	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Y2H Array	25416956
Intra	RASSF5	Q8WWW0	RASSF2	Homo sapiens	P50749	Y2H Prey Pooling	25416956
Intra	RASSF5	Q8WWW0	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
Intra	RASSF5	Q8WWW0	STK3	Homo sapiens	Q13188	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency	Leukocyte Adhesion Deficiency 1
LAD1	Lad
Lymphocyte Function-Associated Antigen 1 Immunodeficiency	Leukocyte Adhesion Deficiency Type I
Leukocyte Adhesion Deficiency Type 1	Linear Iga Bullous Dermatosis
Linear Iga Dermatosis	Leukocyte-Adhesion Deficiency Syndrome
Lfa1 Immunodeficiency	Congenital Leukocyte Adherence Deficiency
Lad-I	Linear Iga Disease
Leukocyte Adhesion Deficiency Syndrome	Lad 1
Lfa 1 Immunodeficiency	Linear Immunoglobulin A Dermatosis
Leucocyte Adhesion Deficiency Type 1	Leukocyte Adhesion Molecule Deficiency Type 1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11705	RASSF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RASSF5	VGNC	VGNC:100051
Rattus norvegicus	RASSF5	RGD	RGD:621694
Canis familiaris	RASSF5	VGNC	VGNC:45382
Mus musculus	RASSF5	MGD	MGI:1926375
Bos taurus	RASSF5	VGNC	VGNC:33761
Felis catus	RASSF5	VGNC	VGNC:64508

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