CACNG7 - calcium voltage-gated channel auxiliary subunit gamma 7 Gene

Homo sapiens

Gene ID: 59284 | Gene type: protein coding

About CACNG7

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,909,278-53,943,950 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 5 paralogues. Restricted expression toward brain (RPKM 18.0).

Summary

The protein encoded by this gene is a type II transmembrane AMPA Receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a Calcium Channel gamma subunit. [provided by RefSeq, Dec 2010]

CACNG7 Products(3)

mRNA	Protein	Name
NM_001384801.1	NP_001371730.1	voltage-dependent calcium channel gamma-7 subunit isoform 2
NM_001412134.1	NP_001399063.1	voltage-dependent calcium channel gamma-7 subunit isoform 3
NM_031896.5	NP_114102.2	voltage-dependent calcium channel gamma-7 subunit isoform 1

CACNG7 Protein Structure

PMP22_Claudin

0
100
200
275 a.a.

Protein Preferred Names

Protein Names

voltage-dependent calcium channel gamma-7 subunit

TARP gamma-7

CACNG7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CACNG7	P62955	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	CACNG7	P62955	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	CACNG7	P62955	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23	SCA23
Ataxia, Spinocerebellar, Type 23

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01814	CACNG7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CACNG7	VGNC	VGNC:26692
Mus musculus	CACNG7	MGD	MGI:1932374
Macaca mulatta	CACNG7	VGNC	VGNC:70484
Felis catus	CACNG7	VGNC	VGNC:60312
Rattus norvegicus	CACNG7	RGD	RGD:628807
Canis familiaris	CACNG7	VGNC	VGNC:53674

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