2. Gene
  3. SPACA1 - sperm acrosome associated 1 Gene

SPACA1 - sperm acrosome associated 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAMP32

Gene ID: 81833 | Gene type: protein coding

About SPACA1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:88,046,901-88,066,838 (from NCBI)

This gene has 3 transcripts (splice variants) and 116 orthologues. Restricted expression toward testis (RPKM 11.4).

Summary

The correlation of anti-sperm Antibodies with cases of unexplained infertility implicates a role for these Antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm Antibodies from infertile males. Furthermore, Antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

SPACA1 Products(1)

mRNA Protein Name
NM_030960.3 NP_112222.1 sperm acrosome membrane-associated protein 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sperm acrosome membrane-associated protein 1

sperm acrosomal membrane-associated protein 32

SPACA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPACA1 Q9HBV2 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
SPACA1 Q9HBV2 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
SPACA1 Q9HBV2 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 9

Male Infertility Due To Globozoospermia

SPGF9

Male Infertility Due To Round-Headed Spermatozoa

Globozoospermia, Complete

Globozoospermia, Total

Globozoospermia

Globozoospermia Syndrome

Round-Headed Sperm Syndrome

Globozoospermia Complete

Globozoospermia Total
Atrophy Of Prostate
Chronic Salpingitis
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Oligoasthenoteratozoospermia

Oat

Oligoasthenoteratospermia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13615 SPACA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPACA1 MGD MGI:1914902
Macaca mulatta SPACA1 VGNC VGNC:77924
Rattus norvegicus SPACA1 RGD RGD:1560284
Felis catus SPACA1 VGNC VGNC:65590
Bos taurus SPACA1 VGNC VGNC:35161
Canis familiaris SPACA1 VGNC VGNC:46692