RBBP7 - RB binding protein 7, chromatin remodeling factor Gene

Homo sapiens

Also known as RbAp46

Gene ID: 5931 | Gene type: protein coding

About RBBP7

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:16,844,341-16,870,362 (from NCBI)

This gene has 12 transcripts (splice variants), 234 orthologues and 9 paralogues. Ubiquitous expression in adrenal (RPKM 151.2), testis (RPKM 63.0) and 24 other tissues.

Summary

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

RBBP7 Products(2)

mRNA	Protein	Name
NM_001198719.2	NP_001185648.1	histone-binding protein RBBP7 isoform 1
NM_002893.4	NP_002884.1	histone-binding protein RBBP7 isoform 2

RBBP7 Protein Structure

CAF1C_H4-bd

WD40

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

histone-binding protein RBBP7

G1/S transition control protein-binding protein RbAp46

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11719	RBBP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RBBP7	RGD	RGD:620125
Mus musculus	RBBP7	MGD	MGI:1194910
Macaca mulatta	RBBP7	VGNC	VGNC:76678
Felis catus	RBBP7	VGNC	VGNC:69258
Bos taurus	RBBP7	VGNC	VGNC:33772
Canis familiaris	RBBP7	VGNC	VGNC:45393

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