2. Gene
  3. Sik1 - salt-inducible kinase 1 Gene

Sik1 - salt-inducible kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Sik; Snf1lk

Gene ID: 59329 | Gene type: protein coding

About Sik1

Primary_assembly 20: 9,947,396-9,958,991 reverse strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 236 orthologues, 26 paralogues and is associated with 15 phenotypes. Biased expression in Lung (RPKM 8.3), Spleen (RPKM 72.) and 9 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in negative regulation of transcription by RNA polymerase II; protein phosphorylation; and regulation of sodium ion transport. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sik1 Products(1)

mRNA Protein Name
NM_021693.3 NP_067725.2 serine/threonine-protein kinase SIK1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17939993 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17939993 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17939993 RGD
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
12530631 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12530631 RGD
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
12530631 RGD
involved in regulation of sodium ion transport IDA
IDA: Inferred from direct assay
17939993 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sik1 Protein Structure

STKc_SIK

STKc_SIK: cd14071 (25 - 277)

UBA_SIK1

UBA_SIK1: cd14408 (299 - 348)

  • 0
  • 200
  • 400
  • 600
  • 776 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase SIK1

SIK-1

SNF1-like kinase

protein kinase KID2

salt-inducible protein kinase 1

serine/threonine-protein kinase SNF1-like kinase 1

serine/threonine-protein kinase SNF1LK

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15776 HG-9-91-01 Inhibitor 99.77% Unkown
HY-101147 YKL-05-099 Inhibitor 99.76% Unkown
HY-120877 MRT199665 Inhibitor 99.74% Unkown
HY-120856 ARN-3236 Inhibitor 98.60% Unkown
HY-157442 GLPG3312 Inhibitor 98.25% Unkown
HY-120056 YKL-06-061 Inhibitor 99.21% Unkown
HY-139253 MRIA9 Inhibitor 98.80% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sik1 NCBI NCBI:150094