RCN1 - reticulocalbin 1 Gene

Homo sapiens

Also known as RCN; RCAL; PIG20; HEL-S-84

Gene ID: 5954 | Gene type: protein coding

About RCN1

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,091,074-32,105,722 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 4 paralogues. Ubiquitous expression in placenta (RPKM 69.9), urinary bladder (RPKM 61.7) and 24 other tissues.

Summary

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity CA(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate Cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]

RCN1 Products(1)

mRNA	Protein	Name
NM_002901.4	NP_002892.1	reticulocalbin-1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCN1 Protein Structure

EF-hand_7

EF-hand_6

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

reticulocalbin-1

epididymis secretory protein Li 84

RCN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RCN1	Q15293	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
Intra	RCN1	Q15293	ZNF410	Homo sapiens	Q86VK4-3	Validated Y2H	32296183
Intra	RCN1	Q15293	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	RCN1	Q15293	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	RCN1	Q15293	DCAF11	Homo sapiens	Q8TEB1	Validated Y2H	32296183
Intra	RCN1	Q15293	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RCN1	Q15293	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RCN1	Q15293	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RCN1	Q15293	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
Intra	RCN1	Q15293	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183
Intra	RCN1	Q15293	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	RCN1	Q15293	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	RCN1	Q15293	ATXN1	Homo sapiens	P54253	Y2H	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RCN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71820	RCN1 Protein, Human (P.pastoris, His)	Q15293-1 (31P-L331)	≥95%

Related Diseases

Diseases

Alias

Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome	11p Partial Monosomy Syndrome
Chromosome 11p13 Deletion Syndrome	Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome
11p Deletion Syndrome	Chromosome 11p Deletion Syndrome
Wagr Complex	Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome
Deletion 11p13	WAGR
Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome	Chromosome 11p Deletion
11p Deletion	11p Monosomy
Deletion 11p	Monosomy 11p
Partial Monosomy 11p	Agr Triad
Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome	Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome
Wagr Contiguous Gene Syndrome	Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome
Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome	Del(11)(P13)
Monosomy 11p13	Chromosome 11, Deletion 11p

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Aniridia 1

Aniridia	Congenital Aniridia
AN1	An
Cataract With Late-Onset Corneal Dystrophy	Aplasia Of Iris
Absent Iris	Irideremia
Aniridia Ii, Formerly	An2, Formerly
An2	Aniridia Type Ii
Aniridia, Type 1	An-1
Absence Of Iris	Agenesis Of Iris
Congenital Absence Of Iris	Hereditary Aniridia
Sporadic Aniridia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11788	RCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RCN1	MGD	MGI:104559
Rattus norvegicus	RCN1	RGD	RGD:1311292
Bos taurus	RCN1	VGNC	VGNC:33831
Canis familiaris	RCN1	VGNC	VGNC:52039
Macaca mulatta	RCN1	VGNC	VGNC:101389
Felis catus	RCN1	VGNC	VGNC:81953
Others	RCN1	NCBI

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