TSKS - testis specific serine kinase substrate Gene

Homo sapiens

Also known as TSKS1; TSSKS; STK22S1; PPP1R161

Gene ID: 60385 | Gene type: protein coding

About TSKS

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,739,760-49,763,306 (from NCBI)

This gene has 3 transcripts (splice variants) and 101 orthologues. Restricted expression toward testis (RPKM 31.5).

Summary

This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular Cancer. The gene is localized to the region 19q13.3 among the related Ras viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

TSKS Products(1)

mRNA	Protein	Name
NM_021733.2	NP_068379.1	testis-specific serine kinase substrate

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15044604	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18533145	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	18495105	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSKS Protein Structure

TSKS

0
100
200
300
400
500
592 a.a.

Protein Preferred Names

Protein Names

testis-specific serine kinase substrate

STK22 substrate 1

TSKS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSKS	Q9UJT2	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	TSKS	Q9UJT2	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	TSKS	Q9UJT2	TPM3	Homo sapiens	P06753	Y2H Array	32296183
Intra	TSKS	Q9UJT2	TPM3	Homo sapiens	P06753	Y2H Prey Pooling	32296183
Intra	TSKS	Q9UJT2	TSSK1B	Homo sapiens	Q9BXA7	Y2H Array	32296183
Intra	TSKS	Q9UJT2	TSSK1B	Homo sapiens	Q9BXA7	Y2H Prey Pooling	32296183
Intra	TSKS	Q9UJT2	TSSK2	Homo sapiens	Q96PF2	Y2H Array	32296183
Intra	TSKS	Q9UJT2	TSSK2	Homo sapiens	Q96PF2	Y2H	15044604
Intra	TSKS	Q9UJT2	TSSK2	Homo sapiens	Q96PF2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15151	TSKS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TSKS	VGNC	VGNC:47906
Bos taurus	TSKS	VGNC	VGNC:36421
Rattus norvegicus	TSKS	RGD	RGD:727784
Felis catus	TSKS	VGNC	VGNC:66620
Macaca mulatta	TSKS	VGNC	VGNC:79868
Mus musculus	TSKS	MGD	MGI:1347560

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