TSSK2 - testis specific serine kinase 2 Gene

Homo sapiens

Also known as TSK2; DGS-G; SPOGA2; STK22B

Gene ID: 23617 | Gene type: protein coding

About TSSK2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:19,131,308-19,132,622 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues and 17 paralogues.

Summary

TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

TSSK2 Products(1)

mRNA	Protein	Name
NM_053006.5	NP_443732.3	testis-specific serine/threonine-protein kinase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables magnesium ion binding	IDA IDA: Inferred from direct assay	20729278	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15044604	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18533145	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	20729278	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSSK2 Protein Structure

Pkinase

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

testis-specific serine/threonine-protein kinase 2

TSK-2

TSSK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSSK2	Q96PF2	FAM229B	Homo sapiens	Q4G0N7	Y2H Prey Pooling	32296183
Intra	TSSK2	Q96PF2	FAM229B	Homo sapiens	Q4G0N7	Y2H Array	32296183
Intra	TSSK2	Q96PF2	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	TSSK2	Q96PF2	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	TSSK2	Q96PF2	TSEN15	Homo sapiens	Q8WW01	Y2H Array	32296183
Intra	TSSK2	Q96PF2	TSEN15	Homo sapiens	Q8WW01	Y2H Prey Pooling	32296183
Intra	TSSK2	Q96PF2	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	TSSK2	Q96PF2	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	TSSK2	Q96PF2	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	TSSK2	Q96PF2	TSKS	Homo sapiens	Q9UJT2	Y2H Prey Pooling	32296183
Intra	TSSK2	Q96PF2	TSKS	Homo sapiens	Q9UJT2	Pull Down	15044604
Intra	TSSK2	Q96PF2	TSKS	Homo sapiens	Q9UJT2	Y2H Array	32296183
Intra	TSSK2	Q96PF2	TSKS	Homo sapiens	Q9UJT2	Validated Y2H	32296183
Intra	TSSK2	Q96PF2	TSKS	Homo sapiens	Q9UJT2-2	Protein Kinase Assay	15044604

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hyperprolinemia, Type I

Proline Oxidase Deficiency	Hyperprolinemia Type 1
HYRPRO1	Hpi
Hyperprolinemia Type I	Hyperprolinemia 1
Proline Dehydrogenase Deficiency

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

Van Den Ende-Gupta Syndrome

VDEGS	Blepharophimosis, Arachnodactyly, And Congenital Contractures
Marden-Walker-Like Syndrome	Marden-Walker-Like Syndrome Without Psychomotor Retardation
Marden Walker Like Syndrome	Marden-Walker-Like Syndrome Without Psychmotor Retardation
Van Den Ende Gupta Syndrome	Marden Walker Like Syndrome Without Psychomotor Retardation
Blepharophimosis Arachnodactyly And Congenital Contractures

Combined D-2- And L-2-Hydroxyglutaric Aciduria

D,L-2-Hydroxyglutaric Aciduria	D2L2AD
Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia	Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria
D,L-2-Hga	D,L-2-Hydroxyglutaric Acidemia
Combined D,L-2-Hydroxyglutaric Aciduria

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15358	ALK inhibitor 2	Inhibitor	99.57%	Unkown
HY-15357	ALK inhibitor 1	Inhibitor	99.62%	Unkown
HY-RS15188	TSSK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TSSK2	VGNC	VGNC:78557
Mus musculus	TSSK2	MGD	MGI:1347559
Felis catus	TSSK2	VGNC	VGNC:66644
Rattus norvegicus	TSSK2	RGD	RGD:1304951
Canis familiaris	TSSK2	VGNC	VGNC:103714
Bos taurus	TSSK2	VGNC	VGNC:49975
Others	TSSK2	NCBI

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