2. Gene
  3. TRMT11 - tRNA methyltransferase 11 homolog Gene

TRMT11 - tRNA methyltransferase 11 homolog Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TRM11; MDS024; C6orf75; TRMT11-1

Gene ID: 60487 | Gene type: protein coding

About TRMT11

This gene has 12 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in endometrium (RPKM 2.2), duodenum (RPKM 1.9) and 25 other tissues.

Summary

Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRMT11 Products(19)

mRNA Protein Name
NM_001031712.3 NP_001026882.2 tRNA (guanine(10)-N2)-methyltransferase homolog isoform a
NM_001350580.2 NP_001337509.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform b
NM_001350581.2 NP_001337510.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform c
NM_001350582.2 NP_001337511.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform c
NM_001350583.2 NP_001337512.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform c
NM_001350584.2 NP_001337513.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform c
NM_001350585.2 NP_001337514.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform d
NM_001350586.2 NP_001337515.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350587.2 NP_001337516.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350588.2 NP_001337517.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350589.2 NP_001337518.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350590.2 NP_001337519.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350591.2 NP_001337520.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350592.2 NP_001337521.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350593.2 NP_001337522.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350594.2 NP_001337523.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350595.2 NP_001337524.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350596.2 NP_001337525.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
NM_001350597.2 NP_001337526.1 tRNA (guanine(10)-N2)-methyltransferase homolog isoform e
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT11 Protein Structure

UPF0020

UPF0020: Putative RNA methylase family UPF0020 (190 - 319)

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  • 463 a.a.
Protein Preferred Names Protein Names

tRNA (guanine(10)-N2)-methyltransferase homolog

tRNA guanosine-2'-O-methyltransferase TRM11 homolog

TRMT11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRMT11 Q7Z4G4 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
TRMT11 Q7Z4G4 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
TRMT11 Q7Z4G4 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
TRMT11 Q7Z4G4 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
TRMT11 Q7Z4G4 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
TRMT11 Q7Z4G4 LHX4 Homo sapiens Q969G2
Validated Y2H
32296183
Intra
TRMT11 Q7Z4G4 TRMT112 Homo sapiens Q9UI30
Anti Tag CoIP
34948388
Intra
TRMT11 Q7Z4G4 TRMT112 Homo sapiens Q9UI30
Confocal
34948388
Intra
TRMT11 Q7Z4G4 TRMT112 Homo sapiens Q9UI30
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 7

COXPD7

Combined Oxidative Phosphorylation Defect Type 7

Severe C12orf65-Related Combined Oxidative Phosphorylation Defect

Severe C12orf65-Related Coxpd

Combined Oxidative Phosphorylation Deficiency, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15089 TRMT11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TRMT11 VGNC VGNC:47854
Rattus norvegicus TRMT11 RGD RGD:727798
Bos taurus TRMT11 VGNC VGNC:36368
Macaca mulatta TRMT11 VGNC VGNC:79306
Felis catus TRMT11 VGNC VGNC:66568
Mus musculus TRMT11 MGD MGI:1920931
Others TRMT11 NCBI