Unc5b - unc-5 netrin receptor B Gene

Rattus norvegicus

Also known as Unc5h2

Gene ID: 60630 | Gene type: protein coding

About Unc5b

Summary

Enables netrin receptor activity. Involved in axon guidance and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in membrane raft. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Apr 2022]

Unc5b Products(1)

mRNA	Protein	Name
NM_022207.2	NP_071543.2	netrin receptor UNC5B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables netrin receptor activity	IDA IDA: Inferred from direct assay	9126742	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18469807	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon guidance	IDA IDA: Inferred from direct assay	9126742	RGD
acts upstream of or within axon guidance	IGI IGI: Inferred from genetic interaction	21673655	RGD
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	21172653	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane raft	IDA IDA: Inferred from direct assay	21172653	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

netrin receptor UNC5B

protein unc-5 homolog 2	protein unc-5 homolog B
transmembrane receptor Unc5H2	unc-5 homolog 2
unc-5 homolog B

Unc5b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Unc5b	O08722	PPP2R1B	Homo sapiens	P30154	Y2H	21172653
Intra	Unc5b	O08722	Agap2	Rattus norvegicus	Q8CGU4	Anti Bait CoIP	18469807
Intra	Unc5b	O08722	Agap2	Rattus norvegicus	Q8CGU4	Confocal	18469807

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Unc5b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76120	UNC5B Protein, Rat (HEK293, Fc)	O08722/NP_071543.1 (G27-D373)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15472	UNC5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Unc5b	NCBI	NCBI:219699

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