PPP2R1B - protein phosphatase 2 scaffold subunit Abeta Gene

Homo sapiens

Also known as PR65B; PP2A-Abeta

Gene ID: 5519 | Gene type: protein coding

About PPP2R1B

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,688,000-111,766,389 (from NCBI)

This gene has 12 transcripts (splice variants), 192 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues.

Summary

This gene encodes a constant regulatory subunit of protein Phosphatase 2. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R1B Products(5)

mRNA	Protein	Name
NM_001177562.2	NP_001171033.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d
NM_001177563.2	NP_001171034.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform e
NM_002716.5	NP_002707.3	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a
NM_181699.3	NP_859050.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b
NM_181700.2	NP_859051.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8392071	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	21172653	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	21172653	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane raft	IDA IDA: Inferred from direct assay	21172653	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R1B Protein Structure

HEAT

HEAT_2

0
100
200
300
400
500
601 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

protein phosphatase 2, regulatory subunit A, beta

PPP2R1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2R1B	P30154	RALA	Homo sapiens	P11233	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2R5C	Homo sapiens	Q13362	Pull Down	16456541
Intra	PPP2R1B	P30154	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
Intra	PPP2R1B	P30154	PPP2R5D	Homo sapiens	Q14738	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2CA	Homo sapiens	P67775	Chromatography	8392071
Intra	PPP2R1B	P30154	PPP2R5E	Homo sapiens	Q16537	Anti Tag CoIP	17540176
Cross	PPP2R1B	P30154	Unc5b	Rattus norvegicus	O08722	Anti Bait CoIP	21172653
Cross	PPP2R1B	P30154	Unc5b	Rattus norvegicus	O08722	GMS	21172653
Cross	PPP2R1B	P30154	Unc5b	Rattus norvegicus	O08722	Anti Tag CoIP	21172653

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11010	PPP2R1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP2R1B	MGD	MGI:1920949
Rattus norvegicus	PPP2R1B	RGD	RGD:1304764
Macaca mulatta	PPP2R1B	VGNC	VGNC:76375
Felis catus	PPP2R1B	VGNC	VGNC:69010
Bos taurus	PPP2R1B	VGNC	VGNC:33254
Canis familiaris	PPP2R1B	VGNC	VGNC:44906

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