RPS5 - ribosomal protein S5 Gene

Homo sapiens

Also known as S5

Gene ID: 6193 | Gene type: protein coding

About RPS5

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,387,269-58,394,804 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 988.2), bone marrow (RPKM 469.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS5 Products(1)

mRNA	Protein	Name
NM_001009.4	NP_001000.2	40S ribosomal protein S5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	18464793	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24965446	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of translational fidelity	IGI IGI: Inferred from genetic interaction	17901157	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in translation	IGI IGI: Inferred from genetic interaction	17901157	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS5 Protein Structure

Ribosomal_S7

0
100
204 a.a.

Protein Preferred Names

Protein Names

40S ribosomal protein S5

small ribosomal subunit protein uS7

RPS5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPS5	P46782	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RPS5	P46782	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RPS5	P46782	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RPS5	P46782	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	RPS5	P46782	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	RPS5	P46782	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 14

RP14	Retinitis Pigmentosa Juvenile Tulp1-Related
Retinitis Pigmentosa-14	Retinitis Pigmentosa, Type 14

Erythroleukemia

Axonal Neuropathy

Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes	ASGD5
Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12246	RPS5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPS5	VGNC	VGNC:64753
Bos taurus	RPS5	VGNC	VGNC:34139
Macaca mulatta	RPS5	VGNC	VGNC:103858
Rattus norvegicus	RPS5	RGD	RGD:3601
Mus musculus	RPS5	MGD	MGI:1097682
Canis familiaris	RPS5	VGNC	VGNC:45737

Name
Email *

	Sorry, but the email address you supplied was invalid.