RPS6KA2 - ribosomal protein S6 kinase A2 Gene

Homo sapiens

Also known as RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2

Gene ID: 6196 | Gene type: protein coding

About RPS6KA2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:166,409,364-166,862,773 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 23.1), lung (RPKM 22.2) and 24 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

RPS6KA2 Products(9)

mRNA	Protein	Name
NM_001318938.1	NP_001305867.1	ribosomal protein S6 kinase alpha-2 isoform e
NM_001006932.3	NP_001006933.3	ribosomal protein S6 kinase alpha-2 isoform b
NM_001318936.2	NP_001305865.2	ribosomal protein S6 kinase alpha-2 isoform c
NM_001318937.2	NP_001305866.1	ribosomal protein S6 kinase alpha-2 isoform d
XM_006715549.4	XP_006715612.1	ribosomal protein S6 kinase alpha-2 isoform X1
XM_047419233.1	XP_047275189.1	ribosomal protein S6 kinase alpha-2 isoform X2
XM_047419235.1	XP_047275191.1	ribosomal protein S6 kinase alpha-2 isoform X4
XM_047419234.1	XP_047275190.1	ribosomal protein S6 kinase alpha-2 isoform X3
NM_021135.6	NP_066958.2	ribosomal protein S6 kinase alpha-2 isoform a

RPS6KA2 Protein Structure

Pkinase

Pkinase_C

Pkinase

0
200
400
600
733 a.a.

Protein Preferred Names

Protein Names

ribosomal protein S6 kinase alpha-2

MAP kinase-activated protein kinase 1c	MAPK-activated protein kinase 1c
mitogen-activated protein kinase-activated protein kinase 1C	ribosomal S6 kinase 3
ribosomal protein S6 kinase, 90kDa, polypeptide 2

Recombinant RPS6KA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76011	RSK3 Protein, Human (sf9, GST)	Q15349-1 (M1-L733)	≥95%

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Coffin-Lowry Syndrome

CLS	Mental Retardation With Osteocartilaginous Abnormalities
Coffin Syndrome 1	Coffin Syndrome
Dwarfism, Lean Spastic Type	Lean Spastic Dwarfism
Coffin Lowry Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12251	RPS6KA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12252	Rps6ka2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12253	Rps6ka2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RPS6KA2	VGNC	VGNC:76928
Bos taurus	RPS6KA2	VGNC	VGNC:34141
Felis catus	RPS6KA2	VGNC	VGNC:64755
Rattus norvegicus	RPS6KA2	RGD	RGD:620676
Mus musculus	RPS6KA2	MGD	MGI:1342290
Canis familiaris	RPS6KA2	VGNC	VGNC:45739
Others	RPS6KA2	NCBI

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