2. Gene
  3. S100A10 - S100 calcium binding protein A10 Gene

S100A10 - S100 calcium binding protein A10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 42C; P11; p10; GP11; ANX2L; CAL1L; CLP11; Ca[1]; ANX2LG

Gene ID: 6281 | Gene type: protein coding

About S100A10

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,982,915-151,993,859 (from NCBI)

This gene has 4 transcripts (splice variants), 246 orthologues and 21 paralogues. Broad expression in colon (RPKM 299.3), esophagus (RPKM 210.9) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

S100A10 Products(1)

mRNA Protein Name
NM_002966.3 NP_002957.1 protein S100-A10
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables lipid binding IDA
IDA: Inferred from direct assay
23861394 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14699089 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
23091277 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
12198146 GOA
Biological Process GO Annotation Evidence Reference Source
involved in membrane raft assembly IDA
IDA: Inferred from direct assay
23861394 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
23129259 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
23129259 GOA
involved in positive regulation of plasminogen activation IDA
IDA: Inferred from direct assay
9836589 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
23129259 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
23129259 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
12198146 GOA
involved in vesicle budding from membrane IDA
IDA: Inferred from direct assay
23861394 GOA
Cellular Component GO Annotation Evidence Reference Source
part of AnxA2-p11 complex IDA
IDA: Inferred from direct assay
23091277 GOA
part of RNA polymerase II transcription regulator complex EXP
EXP: Inferred from Experiment
23415230 GOA
colocalizes with membrane raft IDA
IDA: Inferred from direct assay
14699089 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
3126079 GOA
part of plasma membrane protein complex IPI
IPI: Inferred from physical interaction
9886297 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A10 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (5 - 45)

  • 0
  • 97 a.a.
Protein Preferred Names Protein Names

protein S100-A10

S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))

S100A10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
S100A10 P60903 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra
S100A10 P60903 HLTF Homo sapiens Q14527
Pull Down
23415230
Intra
S100A10 P60903 TRPM4 Homo sapiens Q8TD43
FPS
31837246
Intra
S100A10 P60903 S100Z Homo sapiens Q8WXG8
Validated Y2H
32296183
Intra
S100A10 P60903 S100Z Homo sapiens Q8WXG8
Y2H Array
32296183
Intra
S100A10 P60903 S100Z Homo sapiens Q8WXG8
Y2H Prey Pooling
32296183
Intra
S100A10 P60903 MLKL Homo sapiens Q8NB16-2
Y2H Array
32296183
Intra
S100A10 P60903 MLKL Homo sapiens Q8NB16-2
Y2H Prey Pooling
32296183
Intra
S100A10 P60903 MLKL Homo sapiens Q8NB16-2
Validated Y2H
32296183
Intra
S100A10 P60903 AHNAK Homo sapiens Q09666
X-Ray Diffraction
23415230
Intra
S100A10 P60903 ANXA2 Homo sapiens P07355
Crosslink
30021884
Intra
S100A10 P60903 ANXA2 Homo sapiens P07355
Anti Bait CoIP
24457100
Intra
S100A10 P60903 ANXA2 Homo sapiens P07355
IF
24457100
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A10 Proteins

Cat. No. Product Name Accession Purity
HY-P74586 S100A10 Protein, Human (His) P60903 (P2-K97) ≥95%

Related Diseases

Diseases Alias
Trachea Leiomyoma

Tracheal Neoplasms

Leiomyoma Of The Trachea

Tracheal Neoplasm

Tracheal Leiomyoma
Conjunctival Intraepithelial Neoplasm

Intraepithelial Neoplasia Of Conjunctiva

Conjunctival Intraepithelial Neoplasia
Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136465 A2ti-1 Inhibitor 99.84% Unkown
HY-136466 A2ti-2 Inhibitor 99.27% Unkown
HY-RS12372 S100A10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus S100A10 MGD MGI:1339468
Rattus norvegicus S100A10 RGD RGD:628655
Bos taurus S100A10 VGNC VGNC:34237
Felis catus S100A10 VGNC VGNC:80348
Macaca mulatta S100A10 VGNC VGNC:106491
Others S100A10 NCBI