SERPINB3 - serpin family B member 3 Gene

Homo sapiens

Also known as SCC; T4-A; SCCA1; SSCA1; SCCA-1; HsT1196; SCCA-PD

Gene ID: 6317 | Gene type: protein coding

About SERPINB3

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,655,197-63,661,893 (from NCBI)

This gene has 2 transcripts (splice variants), 223 orthologues and 36 paralogues. Restricted expression toward esophagus (RPKM 424.4).

Summary

Enables cysteine-type endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Involved in several processes, including autocrine signaling; paracrine signaling; and regulation of cellular protein metabolic process. Located in cytoplasmic vesicle; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SERPINB3 Products(1)

mRNA	Protein	Name
NM_006919.3	NP_008850.1	serpin B3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	21383048	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	21383048	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	12975381	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autocrine signaling	IMP IMP: Inferred from mutant phenotype	20527027	GOA
involved in negative regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	21383048	GOA
involved in negative regulation of catalytic activity	IDA IDA: Inferred from direct assay	10956412	GOA
involved in negative regulation of endopeptidase activity	IMP IMP: Inferred from mutant phenotype	21383048	GOA
involved in negative regulation of peptidase activity	IDA IDA: Inferred from direct assay	12949073	GOA
involved in negative regulation of proteolysis	IDA IDA: Inferred from direct assay	12975381	GOA
involved in paracrine signaling	IMP IMP: Inferred from mutant phenotype	20527027	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20527027	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20527027	GOA
involved in positive regulation of endopeptidase activity	IDA IDA: Inferred from direct assay	20527027	GOA
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20527027	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20527027	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	21383048	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	21557262	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20527027	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINB3 Protein Structure

Serpin

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

serpin B3

protein T4-A

SERPINB3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SERPINB3	P29508	SERPINB4	Homo sapiens	P48594	Anti Tag CoIP	33961781
Intra	SERPINB3	P29508	SERPINB4	Homo sapiens	P48594	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINB3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71142	Serpin B3 Protein, Human (HEK293, His)	P29508 (M1-P390)	≥95%

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Otomycosis

Singapore Ear

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Psoriasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12711	SERPINB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SERPINB3	RGD	RGD:1549766

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