CCL3L1 - C-C motif chemokine ligand 3 like 1 Gene

Homo sapiens

Also known as LD78; 464.2; MIP1AP; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA; LD78-beta(1-70)

Gene ID: 6349 | Gene type: protein coding

About CCL3L1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:27,400,001-33,500,000

Summary

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CCL3L1 Products(1)

mRNA	Protein	Name
NM_021006.5	NP_066286.1	C-C motif chemokine 3-like 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL3L1 Protein Structure

IL8

0
93 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 3-like 1

G0/G1 switch regulatory protein 19-2

Recombinant CCL3L1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7231	LD78-beta/CCL3L1 Protein, Human	P16619 (A24-A93)	≥95%
HY-P7769	LD78-beta/CCL3L1 Protein, Human (HEK293 His)	P16619 (A24-A93)	≥95%

Related Diseases

Diseases

Alias

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B0498	Bindarit	Inhibitor	99.53%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02100	CCL3L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL3L1	MGD	MGI:98260

Name
Email *

	Sorry, but the email address you supplied was invalid.