CCL15 - C-C motif chemokine ligand 15 Gene

Homo sapiens

Also known as LKN1; NCC3; SY15; HCC-2; LKN-1; MIP-5; NCC-3; SCYL3; MIP-1D; MRP-2B; SCYA15; HMRP-2B; MIP-1 delta

Gene ID: 6359 | Gene type: protein coding

About CCL15

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,997,582-36,001,553 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 141 orthologues and 25 paralogues. Biased expression in colon (RPKM 21.9), small intestine (RPKM 21.7) and 6 other tissues.

Summary

This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C Chemokine Receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional Peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]

CCL15 Products(1)

mRNA	Protein	Name
NM_032965.6	NP_116741.2	C-C motif chemokine 15 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	15001559	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL15 Protein Structure

IL8

0
100
113 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 15

chemokine (C-C motif) ligand 15

Recombinant CCL15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7266	MIP-5/CCL15 Protein, Human	Q16663 (Q22-I113)	≥95%
HY-P73812	MIP-5/CCL15 Protein, Human (68a.a, His)	Q16663 (S46-I113)	≥95%

Related Diseases

Diseases

Alias

Asymptomatic Neurosyphilis

Neurosyphilis

Neurosyphilis, Asymptomatic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02084	CCL15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCL15	RGD	RGD:1310563

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