CCL25 - C-C motif chemokine ligand 25 Gene

Homo sapiens

Also known as TECK; Ckb15; SCYA25; TECKvar; Ck beta-15

Gene ID: 6370 | Gene type: protein coding

About CCL25

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,052,341-8,062,650 (from NCBI)

This gene has 9 transcripts (splice variants), 59 orthologues and 25 paralogues. Restricted expression toward small intestine (RPKM 203.4).

Summary

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to Chemokine Receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

CCL25 Products(7)

mRNA	Protein	Name
NM_001201359.2	NP_001188288.1	C-C motif chemokine 25 isoform 2 precursor
NM_001394634.1	NP_001381563.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394635.1	NP_001381564.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394636.1	NP_001381565.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394637.1	NP_001381566.1	C-C motif chemokine 25 isoform 1 precursor
NM_001394638.1	NP_001381567.1	C-C motif chemokine 25 isoform 2 precursor
NM_005624.4	NP_005615.2	C-C motif chemokine 25 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR10 chemokine receptor binding	IDA IDA: Inferred from direct assay	10706668	GOA
enables chemokine activity	IDA IDA: Inferred from direct assay	18308860	GOA
enables chemokine receptor binding	IDA IDA: Inferred from direct assay	23341447	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18308860	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12949249	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	18308860	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12949249	GOA
involved in negative regulation of leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	18308860	GOA
involved in positive regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	18308860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL25 Protein Structure

IL8

0
100
150 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 25

chemokine (C-C motif) ligand 25

Recombinant CCL25 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7294	TECK/CCL25 Protein, Human	O15444-1 (Q24-L150)	≥95%

Related Diseases

Diseases

Alias

Ileitis

Crohn'S Ileitis

Ascending Cholangitis

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15724	Vercirnon	Antagonist	98.26%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15724A	Vercirnon sodium	Antagonist	99.13%	Unkown
HY-123763	MLN3126	Antagonist	98.64%	Unkown
HY-RS02095	CCL25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL25	MGD	MGI:1099448
Macaca mulatta	CCL25	VGNC	VGNC:70700
Rattus norvegicus	CCL25	RGD	RGD:1305530
Bos taurus	CCL25	VGNC	VGNC:26951
Canis familiaris	CCL25	VGNC	VGNC:38887
Others	CCL25	NCBI

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