2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. MLN3126

MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx.

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MLN3126 Chemical Structure

MLN3126 Chemical Structure

CAS No. : 628300-71-0

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Based on 1 publication(s) in Google Scholar

MLN3126 Related Antibodies

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View All CCR Isoform Specific Products:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC50 value of 6.3 nM for calcium influx[1].

In Vitro

MLN3126 inhibits CCL25-induced calcium mobilization with an IC50 value of 6.3 nM in CCR9 expressing cells[1].
MLN3126 inhibits the binding of biotinylated CCL25 to CCR9 with an IC50 of 14.2 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MLN3126 Related Antibodies

Cell Invasion Assay[1]

Cell Line: Mouse thymocytes
Concentration: 0.01, 0.03, 0.1, 0.3, 1, 3 μM
Incubation Time: 90 min
Result: Inhibited CCL25-induced chemotaxis of mouse thymocytes.
In Vivo

MLN3126 (2.5% w/w; p.o.) decreases colonic level of IFN-γ, largely produced by T cells[1].
MLN3126 (0.05, 0.25 and 1% (w/w); p.o.) has the potential activity for alleviating inflammatory bowel disease (IBD)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Activated T cell transferred colitis mouse model[1]
Dosage: 0.05, 0.25 and 1% (w/w) (around 4 g/day)
Administration: Oral gavage; 21 days
Result: Blocked CCR9/CCL25 interaction by inhibiting migration of T cells to the colon and resulted in the amelioration of colitis.
Clinical Trial
Molecular Weight

446.90

Formula

C21H19ClN2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(OC(C)C)C=C1)(NC2=CC=C(Cl)C=C2C(C3=CC=[N+]([O-])C=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (55.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2376 mL 11.1882 mL 22.3764 mL
5 mM 0.4475 mL 2.2376 mL 4.4753 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2376 mL 11.1882 mL 22.3764 mL 55.9409 mL
5 mM 0.4475 mL 2.2376 mL 4.4753 mL 11.1882 mL
10 mM 0.2238 mL 1.1188 mL 2.2376 mL 5.5941 mL
15 mM 0.1492 mL 0.7459 mL 1.4918 mL 3.7294 mL
20 mM 0.1119 mL 0.5594 mL 1.1188 mL 2.7970 mL
25 mM 0.0895 mL 0.4475 mL 0.8951 mL 2.2376 mL
30 mM 0.0746 mL 0.3729 mL 0.7459 mL 1.8647 mL
40 mM 0.0559 mL 0.2797 mL 0.5594 mL 1.3985 mL
50 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
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MLN3126 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLN3126628300-71-0MLN 3126MLN-3126CCRCC chemokine receptorChemokine receptorCCR9inflammatory bowel diseaseIBDInhibitorinhibitorinhibit

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