CXCL6 - C-X-C motif chemokine ligand 6 Gene

Homo sapiens

Also known as GCP2; CKA-3; GCP-2; SCYB6

Gene ID: 6372 | Gene type: protein coding

About CXCL6

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,836,678-73,838,760 (from NCBI)

This gene has 3 transcripts (splice variants), 75 orthologues and 12 paralogues. Biased expression in spleen (RPKM 44.2), gall bladder (RPKM 20.7) and 4 other tissues.

Summary

The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has Antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]

CXCL6 Products(1)

mRNA	Protein	Name
NM_002993.4	NP_002984.1	C-X-C motif chemokine 6 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	8399143	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	8399143	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	8399143	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	8399143	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	8399143	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL6 Protein Structure

IL8

0
100
114 a.a.

Protein Preferred Names

Protein Names

C-X-C motif chemokine 6

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

Recombinant CXCL6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72677	GCP-2/CXCL6 Protein, Human (HEK293, His)	P80162 (G38-N114)	≥95%
HY-P700048AF	Animal-Free GCP-2/CXCL6 Protein, Human (His)	P80162 (V40-N114)	≥95%

Related Diseases

Diseases

Alias

Tonsillitis

Chronic Tonsillitis

Throat Infection - Tonsillitis

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Sodoku Disease

Spirillosis	Sodoku
Spirillary Fever	Rat-Bite Fever
Rat-Bite Fever Due To Spirillum Minus	Spirillary Rat-Bite Fever
Sokosho

Gastroduodenitis

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03394	CXCL6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CXCL6	RGD	RGD:708540
Mus musculus	CXCL6	MGD	MGI:1096868
Macaca mulatta	CXCL6	VGNC	VGNC:106565
Others	CXCL6	NCBI

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