2. Gene
  3. SRR - serine racemase Gene

SRR - serine racemase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ILV1; ISO1

Gene ID: 63826 | Gene type: protein coding

About SRR

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,303,378-2,325,264 (from NCBI)

This gene has 8 transcripts (splice variants), 121 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.5), testis (RPKM 6.3) and 25 other tissues.

Summary

Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and anion binding activity. Involved in pyruvate biosynthetic process; response to lipopolysaccharide; and serine family amino acid metabolic process. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

SRR Products(2)

mRNA Protein Name
NM_001304803.1 NP_001291732.1 serine racemase isoform b
NM_021947.3 NP_068766.1 serine racemase isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
20106978 GOA
enables L-serine ammonia-lyase activity IDA
IDA: Inferred from direct assay
18812225 GOA
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
16314870 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15681805 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
20106978 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20106978 GOA
enables pyridoxal phosphate binding IDA
IDA: Inferred from direct assay
20106978 GOA
enables serine racemase activity IDA
IDA: Inferred from direct assay
11054547 GOA
Biological Process GO Annotation Evidence Reference Source
involved in D-serine biosynthetic process IDA
IDA: Inferred from direct assay
11054547 GOA
involved in D-serine metabolic process IDA
IDA: Inferred from direct assay
20106978 GOA
involved in L-serine metabolic process IDA
IDA: Inferred from direct assay
11054547 GOA
involved in pyruvate biosynthetic process IDA
IDA: Inferred from direct assay
18812225 GOA
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15681805 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16314870 GOA
located in neuronal cell body IDA
IDA: Inferred from direct assay
17880399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRR Protein Structure

PALP

PALP: Pyridoxal-phosphate dependent enzyme (21 - 314)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

serine racemase

D-serine ammonia-lyase

SRR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra
SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra
SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra
SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Y2H Prey Pooling
32296183
Intra
SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Validated Y2H
32296183
Intra
SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 24

Severe Combined Immunodeficiency Due To Ctps1 Deficiency

IMD24

Scid Due To Ctps1 Deficiency

Immunodeficiency, Type 24
Serine Deficiency
Glanders

Farcy Pipes

Infection Due To Pseudomonas Mallei

Burkholderia Mallei

Burkholderia Mallei Infection

Equina

Equine Glanders

Farcy

Farcy Buds

Farcy Cords

Infection Due To Actinobacillus Mallei

Infection Due To Malleomyces Mallei

Maliasmus

Malleus

Farce

Actinobacillosis

Actinobacillus Infection
Subacute Bacterial Endocarditis

Endocarditis Lenta

Sbe - Subacute Bacterial Endocarditis

Subacute Endocarditis, Lenta

Endocarditis, Subacute Bacterial
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome

Mental Retardation, X-Linked, Snyder-Robinson Type

Spermine Synthase Deficiency

Srs

Snyder-Robinson Mental Retardation Syndrome

X-Linked Intellectual Disability Snyder-Robinson Type

Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

Snyder-Robinson X-Linked Mental Retardation Syndrome
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13784 SRR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SRR RGD RGD:735094
Felis catus SRR VGNC VGNC:65689
Bos taurus SRR VGNC VGNC:35292
Mus musculus SRR MGD MGI:1351636