RNF41 - ring finger protein 41 Gene

Homo sapiens

Also known as FLRF; NRDP1; SBBI03

Gene ID: 10193 | Gene type: protein coding

About RNF41

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,202,179-56,221,969 (from NCBI)

This gene has 12 transcripts (splice variants), 223 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 10.6), prostate (RPKM 9.7) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin Ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

RNF41 Products(4)

mRNA	Protein	Name
NM_001242826.2	NP_001229755.1	E3 ubiquitin-protein ligase NRDP1 isoform 1
NM_005785.4	NP_005776.1	E3 ubiquitin-protein ligase NRDP1 isoform 1
NM_194358.3	NP_919339.1	E3 ubiquitin-protein ligase NRDP1 isoform 2
NM_194359.2	NP_919340.1	E3 ubiquitin-protein ligase NRDP1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22493164	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11867753	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	27353365	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	27353365	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	18541373	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14765125	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14765125	GOA
acts upstream of or within negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17145873	GOA
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17145873	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	27353365	GOA
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	18541373	GOA
involved in proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	18541373	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	24105792	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	14765125	GOA
acts upstream of or within regulation of MAPK cascade	IDA IDA: Inferred from direct assay	17145873	GOA
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	17145873	GOA
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	18541373	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum tubular network	IDA IDA: Inferred from direct assay	27353365	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	27353365	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF41 Protein Structure

zf-C3HC4

USP8_interact

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase NRDP1

RING-type E3 ubiquitin transferase NRDP1

RNF41 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF41	Q9H4P4	ARL6IP4	Homo sapiens	Q66PJ3-3	Y2H Array	25416956
Intra	RNF41	Q9H4P4	ISCA2	Homo sapiens	Q86U28	Y2H Array	25416956
Intra	RNF41	Q9H4P4	ISCA2	Homo sapiens	Q86U28	Y2H Array	32296183
Intra	RNF41	Q9H4P4	ISCA2	Homo sapiens	Q86U28	Y2H Prey Pooling	32296183
Intra	RNF41	Q9H4P4	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RNF41	Q9H4P4	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RNF41	Q9H4P4	HOMER2	Homo sapiens	Q9NSB8	Y2H Array	25416956
Intra	RNF41	Q9H4P4	ASB6	Homo sapiens	Q9NWX5	Validated Y2H	32296183
Intra	RNF41	Q9H4P4	ASB6	Homo sapiens	Q9NWX5	Y2H Array	25416956
Intra	RNF41	Q9H4P4	TTC1	Homo sapiens	Q99614	Validated Y2H	25416956
Intra	RNF41	Q9H4P4	TTC1	Homo sapiens	Q99614	Y2H Array	25416956
Intra	RNF41	Q9H4P4	N4BP3	Homo sapiens	O15049	Y2H Array	32296183
Intra	RNF41	Q9H4P4	N4BP3	Homo sapiens	O15049	Anti Tag CoIP	26496610
Intra	RNF41	Q9H4P4	N4BP3	Homo sapiens	O15049	Y2H Prey Pooling	32296183
Intra	RNF41	Q9H4P4	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	25416956
Intra	RNF41	Q9H4P4	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	RNF41	Q9H4P4	VPS52	Homo sapiens	Q8N1B4	Anti Tag CoIP	33961781
Intra	RNF41	Q9H4P4	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	RNF41	Q9H4P4	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	RNF41	Q9H4P4	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	RNF41	Q9H4P4	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	RNF41	Q9H4P4	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	RNF41	Q9H4P4	RFC4	Homo sapiens	P35249	Y2H Array	25416956
Intra	RNF41	Q9H4P4	ENOPH1	Homo sapiens	Q9UHY7	Y2H Array	32296183
Intra	RNF41	Q9H4P4	ENOPH1	Homo sapiens	Q9UHY7	Y2H Prey Pooling	32296183
Intra	RNF41	Q9H4P4	ENOPH1	Homo sapiens	Q9UHY7	Validated Y2H	32296183
Intra	RNF41	Q9H4P4	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	RNF41	Q9H4P4	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	RNF41	Q9H4P4	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	RNF41	Q9H4P4	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	RNF41	Q9H4P4	SRR	Homo sapiens	Q9GZT4	Y2H Prey Pooling	32296183
Intra	RNF41	Q9H4P4	SRR	Homo sapiens	Q9GZT4	Anti Tag CoIP	33961781
Intra	RNF41	Q9H4P4	SRR	Homo sapiens	Q9GZT4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12092	RNF41 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF41	MGD	MGI:1914838
Canis familiaris	RNF41	VGNC	VGNC:45670
Bos taurus	RNF41	VGNC	VGNC:34067
Rattus norvegicus	RNF41	RGD	RGD:1309557

Name
Email *

	Sorry, but the email address you supplied was invalid.