THADA - THADA armadillo repeat containing Gene

Homo sapiens

Also known as GITA; ARMC13; Trm732

Gene ID: 63892 | Gene type: protein coding

About THADA

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:43,230,851-43,596,038 (from NCBI)

This gene has 19 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in lymph node (RPKM 6.5), thyroid (RPKM 6.2) and 25 other tissues.

Summary

This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and Apoptosis. [provided by RefSeq, Sep 2016]

THADA Products(7)

mRNA	Protein	Name
NM_001083953.2	NP_001077422.1	thyroid adenoma-associated protein isoform a
NM_001271643.2	NP_001258572.1	thyroid adenoma-associated protein isoform b
NM_001271644.2	NP_001258573.1	thyroid adenoma-associated protein isoform c
NM_001345923.2	NP_001332852.1	thyroid adenoma-associated protein isoform d
NM_001345924.2	NP_001332853.1	thyroid adenoma-associated protein isoform e
NM_001345925.2	NP_001332854.1	thyroid adenoma-associated protein isoform a
NM_022065.5	NP_071348.3	thyroid adenoma-associated protein isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme regulator activity	IGI IGI: Inferred from genetic interaction	25404562	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of lipid homeostasis	IGI IGI: Inferred from genetic interaction	28399403	GOA
involved in negative regulation of endoplasmic reticulum calcium ion concentration	IMP IMP: Inferred from mutant phenotype	28399403	GOA
involved in tRNA methylation	IGI IGI: Inferred from genetic interaction	25404562	GOA
involved in tRNA nucleoside ribose methylation	IGI IGI: Inferred from genetic interaction	35559166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THADA Protein Structure

DUF2428

0
300
600
900
1200
1500
1800
1953 a.a.

Protein Preferred Names

Protein Names

thyroid adenoma-associated protein

Trm732 homolog

THADA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THADA	Q6YHU6	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	THADA	Q6YHU6	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	THADA	Q6YHU6	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	THADA	Q6YHU6	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	THADA	Q6YHU6	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovarian Disease	Polycystic Ovaries
Stein-Leventhal Syndrome	Multicystic Ovaries
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

Wolfram Syndrome 1

WFS1	Didmoad
Wfs	Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome
Wolfram Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14468	THADA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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