MRPS14 - mitochondrial ribosomal protein S14 Gene

Homo sapiens (human)

Also known as S14mt; uS14m; COXPD38; MRP-S14; HSMRPS14; DJ262D12.2

Gene ID: 63931 | Gene type: protein coding

About MRPS14

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

MRPS14 Products(1)

mRNA	Protein	Name
NR_037606.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial translation	IMP IMP: Inferred from mutant phenotype	30358850	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial small ribosomal subunit	IDA IDA: Inferred from direct assay	25838379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

small ribosomal subunit protein uS14m

28S ribosomal protein S14, mitochondrial	mitochondrial 28S ribosomal protein S14
mitochondrial small ribosomal subunit protein uS14m

MRPS14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MRPS14	O60783	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	MRPS14	O60783	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	MRPS14	O60783	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	MRPS14	O60783	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MRPS14	O60783	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MRPS14	O60783	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MRPS14	O60783	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	MRPS14	O60783	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	MRPS14	O60783	GSN	Homo sapiens	P06396	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

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