GSN - gelsolin Gene

Homo sapiens

Also known as ADF; AGEL

Gene ID: 2934 | Gene type: protein coding

About GSN

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:121,201,483-121,332,842 (from NCBI)

This gene has 16 transcripts (splice variants), 271 orthologues, 7 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues.

Summary

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GSN Products(36)

mRNA	Protein	Name
NM_000177.5	NP_000168.1	gelsolin isoform a precursor
NM_001127662.2	NP_001121134.1	gelsolin isoform b
NM_001127663.2	NP_001121135.2	gelsolin isoform f
NM_001127664.2	NP_001121136.1	gelsolin isoform b
NM_001127665.2	NP_001121137.1	gelsolin isoform b
NM_001127666.2	NP_001121138.1	gelsolin isoform c
NM_001127667.2	NP_001121139.1	gelsolin isoform c
NM_001258029.2	NP_001244958.1	gelsolin isoform d
NM_001258030.2	NP_001244959.1	gelsolin isoform e
NM_001353053.1	NP_001339982.1	gelsolin isoform b
NM_001353054.1	NP_001339983.1	gelsolin isoform b
NM_001353055.2	NP_001339984.1	gelsolin isoform b
NM_001353056.2	NP_001339985.1	gelsolin isoform b
NM_001353057.2	NP_001339986.1	gelsolin isoform b
NM_001353058.2	NP_001339987.1	gelsolin isoform b
NM_001353059.2	NP_001339988.1	gelsolin isoform b
NM_001353060.2	NP_001339989.1	gelsolin isoform b
NM_001353061.2	NP_001339990.1	gelsolin isoform b
NM_001353062.1	NP_001339991.1	gelsolin isoform b
NM_001353063.2	NP_001339992.1	gelsolin isoform c
NM_001353064.2	NP_001339993.1	gelsolin isoform c
NM_001353065.2	NP_001339994.1	gelsolin isoform c
NM_001353066.2	NP_001339995.1	gelsolin isoform c
NM_001353067.2	NP_001339996.1	gelsolin isoform c
NM_001353068.2	NP_001339997.1	gelsolin isoform c
NM_001353069.2	NP_001339998.1	gelsolin isoform c
NM_001353070.2	NP_001339999.1	gelsolin isoform c
NM_001353071.2	NP_001340000.1	gelsolin isoform c
NM_001353072.2	NP_001340001.1	gelsolin isoform c
NM_001353073.2	NP_001340002.1	gelsolin isoform c
NM_001353074.2	NP_001340003.1	gelsolin isoform c
NM_001353075.1	NP_001340004.1	gelsolin isoform c
NM_001353076.2	NP_001340005.1	gelsolin isoform g
NM_001353077.1	NP_001340006.1	gelsolin isoform c
NM_001353078.2	NP_001340007.1	gelsolin isoform h
NM_198252.3	NP_937895.1	gelsolin isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	18266911	GOA
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	14596804	GOA
enables myosin II binding	IPI IPI: Inferred from physical interaction	23325791	GOA
enables phosphatidylinositol 3-kinase catalytic subunit binding	IPI IPI: Inferred from physical interaction	30568254	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10793131	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament capping	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in actin filament depolymerization	IDA IDA: Inferred from direct assay	30568254	GOA
involved in actin filament organization	IGI IGI: Inferred from genetic interaction	23575248	GOA
involved in actin filament polymerization	IDA IDA: Inferred from direct assay	3020431	GOA
involved in actin filament polymerization	IMP IMP: Inferred from mutant phenotype	23729654	GOA
involved in actin filament severing	IDA IDA: Inferred from direct assay	3020431	GOA
involved in actin filament severing	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	19904968	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	20393563	GOA
NOT involved in extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	24236012	GOA
involved in hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	22952982	GOA
involved in negative regulation of viral entry into host cell	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in positive regulation of actin nucleation	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	22952982	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22952982	GOA
involved in positive regulation of keratinocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	23729654	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	19549824	GOA
involved in regulation of establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in regulation of plasma membrane raft polarization	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in regulation of podosome assembly	IMP IMP: Inferred from mutant phenotype	24236012	GOA
involved in regulation of receptor clustering	IMP IMP: Inferred from mutant phenotype	23575248	GOA
involved in renal protein absorption	IMP IMP: Inferred from mutant phenotype	24601799	GOA
involved in sequestering of actin monomers	IMP IMP: Inferred from mutant phenotype	19666531	GOA
involved in striated muscle atrophy	IMP IMP: Inferred from mutant phenotype	19549824	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cap	IDA IDA: Inferred from direct assay	23575248	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	23575248	GOA
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	24236012	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23575248	GOA
located in cytosol	IDA IDA: Inferred from direct assay	3020431	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	3020431	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	14596804	GOA
colocalizes with nucleus	IDA IDA: Inferred from direct assay	23729654	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23575248	GOA
located in podosome	IDA IDA: Inferred from direct assay	24236012	GOA
located in sarcoplasm	IDA IDA: Inferred from direct assay	19549824	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSN Protein Structure

Gelsolin

0
200
400
600
782 a.a.

Protein Preferred Names

Protein Names

gelsolin

actin-depolymerizing factor

Related Diseases

Diseases

Alias

Amyloidosis, Finnish Type

Finnish Type Amyloidosis	Meretoja Syndrome
Amyloidosis V	Amyloidosis, Meretoja Type
Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy	Lattice Corneal Dystrophy Type Ii
Familial Amyloidosis, Finnish Type	Familial Amyloid Polyneuropathy Type Iv
Amyloidosis Due To Mutant Gelsolin	Agel Amyloidosis
Gelsolin Amyloidosis	Hereditary Gelsolin Amyloidosis
Lattice Corneal Dystrophy Type Ii Finnish	Gelsolin-Related Amyloidosis
Kymenlaakso Syndrome	Lattice Corneal Dystrophy, Gelsolin Type
Hereditary Amyloidosis, Finnish Type	Lattice Corneal Dystrophy Type 2
Amyloidosis 5	AMYL5
Agel	Familial Amyloidosis Finnish Type
Meretoja Type Amyloidosis	Type Iv Familial Amyloid Polyneuropathy
Familial Amyloid Polyneuropathy, Type V	Familial Amyloid Polyneuropathy, Type Iv

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Hereditary Amyloidosis

Amyloidosis Hereditary	Familial Amyloidosis
Amyloidosis Familial	Amyloidosis, Hereditary
Amyloidosis, Familial	Genetic Amyloidosis
Heredofamilial Amyloidosis

Amyloidosis, Hereditary, Transthyretin-Related

Transthyretin Amyloidosis	Familial Amyloid Polyneuropathy
Ttr Amyloid Neuropathy	Transthyretin Amyloid Neuropathy
Transthyretin Amyloid Polyneuropathy	Fap
Familial Transthyretin Amyloidosis	Amyloidosis Transthyretin Related
Type I Familial Amyloid Polyneuropathy	Familial Amyloid Polyneuropathy Type I
Attrv122i Amyloidosis	Hereditary Amyloidosis, Transthyretin-Related
Amyloid Polyneuropathy, Familial	Attr Amyloidosis
Attrm Amyloidosis	Corino De Andrade'S Disease
Paramyloidosis	Transthyretin-Related Hereditary Amyloidosis
Ttr Amyloidosis	Hereditary Attr Amyloidosis
Portuguese Polyneuritic Amyloidosis	Portuguese Type Familial Amyloid Neuropathy
Swiss Type Amyloid Polyneuropathy	Type Ii Familial Amyloid Polyneuropathy
Attrv30m Amyloidosis	Attrv30m-Related Amyloidosis
Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type	Attr Cardiomyopathy
Attrv122i-Related Amyloidosis	Ttr-Related Amyloid Cardiomyopathy
Ttr-Related Cardiac Amyloidosis	Transthyretin Amyloid Cardiopathy
Transthyretin-Related Familial Amyloid Cardiomyopathy	Amyloidosis, Transthyretin-Related
AMYL-TTR	Amyloidosis I
Amyloidosis Ohio Type	Amyloidosis Type 7
Amyloidosis Vii	Amyloid Polyneuropathy
Attr	Familial Amyloid Polyneuropathy Type Ii
Hereditary Amyloidosis Transthyretin-Related	Leptomeningeal Amyloidosis
Meningocerebrovascular Amyloidosis	Oculoleptomeningeal Amyloidosis
Familial Amyloid Polyneuropathies	Amyloidosis, Leptomeningeal
Senile Cardiac Amyloidosis	Amyloid Neuropathies, Familial
Danish Type Familial Amyloid Cardiomyopathy	Familial Amyloid Neuropathy, Portuguese Type
Amyloid Polyneuropathy, Swiss Type	Hereditary Oculoleptomeningeal Amyloid Angiopathy
Amyloid Neuropathies

Polyneuropathy

Polyneuropathies

Corneal Dystrophy, Gelatinous Drop-Like

Gelatinous Drop-Like Corneal Dystrophy	GDLD
Cdgdl	Corneal Amyloidosis
Lattice Corneal Dystrophy Type Iii	Amyloidosis, Corneal
Amyloid Corneal Dystrophy, Japanese Type	Gdcd
Primary Familial Amyloidosis Of The Cornea	Subepithelial Amyloidosis Of The Cornea
Corneal Dystrophy, Lattice Type 3	Corneal Dystrophy, Lattice Type Iii
Lattice Corneal Dystrophy, Type Iii	Amyloidosis Corneal
Lattice Corneal Dystrophy Type3	Amyloid Corneal Dystrophy Japanese Type
Dystrophy, Corneal, Gelatinous Drop-Like	Amyloid Of Cornea

Corneal Dystrophy

Amyloid Neuropathy

Amyloid Neuropathies

Neuropathy Amyloid

Corneal Dystrophy, Lattice Type I

Lattice Corneal Dystrophy Type I	Lcd1
CDL1	Lcd
Lattice Corneal Dystrophy Type 1	Corneal Dystrophy, Lattice Type 1
Biber-Haab-Dimmer Dystrophy	Lattice Corneal Dystrophy, Type I
Classic Lattice Corneal Dystrophy	Lcdi
Corneal Dystrophy Lattice Type I	Dystrophy, Corneal, Lattice Type I

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Corneal Disease

Corneal Diseases

Corneal Disorders

Cutis Laxa

Generalized Elastolysis	Loose Skin
Dermatolysis	Dermatomegaly
Cutis Laxa Syndrome

Keratoconus

Kc	Conical Cornea
Noninflammatory Corneal Thining	Bulging Cornea
Cornea Conical	Acquired Conus Of Cornea

Radial Neuropathy

Immunoglobulin Heavy Chain Amyloidosis

Ah Amyloidosis	Heavy Chain Amyloidosis
Amyloidosis Derived From Immunoglobulin Heavy Chain	Ig Heavy-Chain-Associated Amyloidosis

Blepharochalasis

Dermatolysis Palpebrarum

Adiposa Ptosis

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Apolipoprotein A-Iv Associated Amyloidosis

Aapoaiv Amyloidosis	Renal Aapoaiv Amyloidosis
Apolipoprotein A-Iv Amyloidosis

Rheumatic Myocarditis

Acute Rheumatic Myocarditis	Active Rheumatic Fever With Myocarditis
Acute Rheumatic Carditis	Rheumatic Degeneration Of Myocardium
Rheumatic Fever With Myocarditis	Rheumatoid Myocarditis
Acute Rheumatic Heart Disease	Acute Rheumatic Fever With Myocarditis
Active Or Acute Rheumatic Myocarditis	Active Rheumatic Myocarditis
Active Rheumatic Progressive Myocarditis	Chronic Active Rheumatic Myocarditis
Old Active Rheumatic Myocarditis	Active Rheumatic Fibroid Myocarditis
Active Rheumatic Interstitial Myocarditis	Acute Or Subacute Rheumatic Myocardial Insufficiency
Acute Rheumatic Toxic Myocarditis	Inactive Or Quiescent Rheumatic Fever With Myocarditis
Inactive Rheumatic Myocarditis	Rheumatic Progressive Myocarditis
Rheumatic Fibroid Myocarditis	Rheumatic Interstitial Myocarditis
Myocardial Degeneration With Rheumatic Fever	Myocardial Insufficiency With Rheumatic Fever
Rheumatic Cardiomyopathy	Dilated Cardiomyopathy Due To Rheumatic Fever
Myocarditis Due To Rheumatic Fever	Rheumatic Myocardial Insufficiency

Tuberous Sclerosis

Tuberous Sclerosis Syndrome	Bourneville'S Disease
Epiloia	Cerebral Sclerosis
Tuberose Sclerosis	Tuberous Sclerosis 1
Bourneville Disease	Bourneville Phakomatosis
Pringle'S Disease

Epithelial-Stromal Tgfbi Dystrophy

Wild-Type Amyloidosis

Senile Systemic Amyloidosis	Attrwt Amyloidosis
Age Related Amyloidosis	Old Age Amyloidosis
Wild-Type Attr Amyloidosis	Wild-Type Transthyretin Cardiac Amyloidosis
Wild Type Attr Amyloidosis	Attrwt-Related Amyloidosis
Wild Type Attr-Related Amyloidosis

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Cerebral Amyloid Angiopathy, App-Related

Hchwad	Amyloidosis, Cerebroarterial, App-Related
Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant	Cerebral Amyloid Angiopathy, App-Related, Dutch Variant
Cerebral Amyloid Angiopathy, App-Related, Iowa Variant	Cerebral Amyloid Angiopathy, App-Related, Italian Variant
Cerebral Amyloid Angiopathy, App-Related, Flemish Variant	Cerebral Amyloid Angiopathy, App-Related, Arctic Variant
Cerebral Amyloid Angiopathy, Dutch, Italian, Iowa, Flemish, Arctic Variants	App-Related Cerebral Amyloid Angiopathy
Abetaa21g Amyloidosis	Abeta Amyloidosis, Italian Type
Abeta Amyloidosis, Arctic Type	Abeta Amyloidosis, Iowa Type
Abeta Amyloidosis, Dutch Type	Hchwa-D
Abeta Amyloidosis, Flemish Type	Abetaa21g-Related Amyloidosis
Hchwa, Flemish Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Flemish Type
Abetae22k Amyloidosis	Hchwa, Italian Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Italian Type	Abetae22g Amyloidosis
Hchwa, Arctic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Arctic Type
Abetad23n Amyloidosis	Hchwa, Iowa Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Iowa Type	Abetal34v Amyloidosis
Abeta Amyloidosis, Piedmont Type	Abetal34v-Related Amyloidosis
Hchwa, Piedmont Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Piedmont Type
Abetae22q Amyloidosis	Hchwa, Dutch Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type	CAA-APP
Amyloidosis Cerebroarterial App-Related	Amyloidosis Hereditary With Cerebral Hemorrhage Dutch Variant
Cerebral Amyloid Angiopathy App-Related Arctic Variant	Cerebral Amyloid Angiopathy App-Related Dutch Variant
Cerebral Amyloid Angiopathy App-Related Flemish Variant	Cerebral Amyloid Angiopathy App-Related Iowa Variant
Cerebral Amyloid Angiopathy App-Related Italian Variant	Familial Occipital Calcifications With Hemorrhagic Strokes Leukoencephalopathy Arterial Dysplasia Dementia
Fochs-Ladd	Hereditary Cerebral Amyloid Angiopathy Dutch Type
Hereditary Cerebral Hemorrhage With Amyloidosis Dutch Type	Hereditary Cerebral Hemorrhage With Amyloidosis Italian Type
Cerebral Hemorrhage With Amyloidosis, Hereditary, Dutch Type

Immunoglobulin Light Chain Amyloidosis

Al Amyloidosis	Primary Amyloidosis
Primary Systemic Amyloidosis	Light Chain Amyloidosis
Amyloidosis Al	Amyloidosis Primary Systemic
Primary Al Amyloidosis	Primary Systemic Al Amyloidosis
Systemic Al Amyloidsis	Systemic Al Amyloidosis
Light-Chain Amyloidosis	Alys Amyloidosis
Familial Amyloid Nephropathy Due To Lysozyme Variant	Familial Renal Amyloidosis Due To Lysozyme Variant
Hereditary Amyloid Nephropathy Due To Lysozyme Variant	Hereditary Renal Amyloidosis Due To Lysozyme Variant
Lysozyme Amyloidosis	Amyloidosis Primary
Immunoglobulin Deposition Disease	Immunoglobulinic Amyloidosis
Amyloid Al

Recurrent Corneal Erosion

Recurrent Erosion Of Cornea	Recurrent Erosion Syndrome
Corneal Erosion	Non-Traumatic Recurrent Erosion Of Cornea

Asymmetric Motor Neuropathy

Cerebral Amyloid Angiopathy, Itm2b-Related, 1

Dementia, Familial British	Fbd
Presenile Dementia With Spastic Ataxia	Familial British Dementia
Abri Amyloidosis	Cerebral Amyloid Angiopathy, British Type
Itm2b-Related Cerebral Amyloid Angiopathy 1	Familial Dementia, British Type
Cerebral Amyloid Angiopathy, Itm2b-Related 1	CAA-ITM2B1
Cerebral Amyloid Angiopathy British Type	Dementia, Familial, British

Epithelial And Subepithelial Dystrophy

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Nerve Compression Syndrome

Entrapment Neuropathies	Compression Neuropathy
Entrapment Neuropathy	Peripheral Nerve Entrapment Syndrome
Nerve Compression Syndromes	Hereditary Liability To Pressure Palsies

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Myopathy

Muscular Diseases

Myopathies

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05867	GSN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GSN	VGNC	VGNC:29680
Rattus norvegicus	GSN	RGD	RGD:1303089
Canis familiaris	GSN	VGNC	VGNC:41532
Macaca mulatta	GSN	VGNC	VGNC:73299
Mus musculus	GSN	MGD	MGI:95851
Felis catus	GSN	VGNC	VGNC:67486