Casp8 - caspase 8 Gene

Rattus norvegicus

Also known as CASP-8

Gene ID: 64044 | Gene type: protein coding

About Casp8

Primary_assembly 9: 60,264,075-60,312,542 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 132 orthologues, 12 paralogues and is associated with 73 phenotypes. Biased expression in Thymus (RPKM 214.2), Spleen (RPKM 146.4) and 8 other tissues.

Summary

Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Located in several cellular components, including cell body; cytosol; and membrane raft. Part of CD95 death-inducing signaling complex. Used to study pre-malignant neoplasm. Biomarker of several diseases, including heart disease (multiple); kidney disease (multiple); retinal detachment; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland Cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (Caspase 8). [provided by Alliance of Genome Resources, Apr 2022]

Casp8 Products(1)

mRNA	Protein	Name
NM_022277.1	NP_071613.1	caspase-8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	16493077	RGD
enables death receptor binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12191471	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables tumor necrosis factor receptor binding	IPI IPI: Inferred from physical interaction	20649583	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16987298	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	10197541	RGD
involved in protein processing	IDA IDA: Inferred from direct assay	16493077	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	18598848	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18598848	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	18269875	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18289516	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD95 death-inducing signaling complex	IDA IDA: Inferred from direct assay	16493077	RGD
located in cell body	IDA IDA: Inferred from direct assay	18096138	RGD
part of death-inducing signaling complex	IDA IDA: Inferred from direct assay	17518537	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15590916	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp8 Protein Structure

DED_Caspase_8_r1

CASc

0
100
200
300
400
482 a.a.

Protein Preferred Names

Protein Names

caspase-8

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153161	CASP8-IN-1	Inhibitor	98.97%	Unkown
HY-P10146	Ac-LETD-CHO	Inhibitor	/	Unkown
HY-RS01965	CASP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01966	Casp8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01967	Casp8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01968	CASP8AP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp8	NCBI	NCBI:841

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