Fadd - Fas associated via death domain Gene

Rattus norvegicus

Also known as Mort1

Gene ID: 266610 | Gene type: protein coding

About Fadd

Summary

Enables protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in kidney development; regulation of necroptotic process; and response to alkaloid. Located in several cellular components, including cell body; membrane raft; and neuron projection. Part of CD95 death-inducing signaling complex. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; mental depression; middle cerebral artery infarction; and obesity. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]

Fadd Products(1)

mRNA	Protein	Name
NM_152937.2	NP_690920.1	FAS-associated death domain protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables death receptor binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19001025	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables receptor serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	26038570	RGD
enables tumor necrosis factor receptor binding	IPI IPI: Inferred from physical interaction	20649583	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IEP IEP: Inferred from expression pattern	18580876	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	27561622	RGD
involved in regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	26038570	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	21925237	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD95 death-inducing signaling complex	IDA IDA: Inferred from direct assay	16493077	RGD
located in cell body	IDA IDA: Inferred from direct assay	18096138	RGD
part of death-inducing signaling complex	IDA IDA: Inferred from direct assay	17518537	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15590916	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

FAS-associated death domain protein

Fas (TNFRSF6)-associated via death domain

protein FADD

Fadd Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fadd	Q8R2E7	Casp8	Rattus norvegicus	Q9JHX4	Anti Bait CoIP	19001025

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14622	Necrostatin 2	Inhibitor	99.92%	Unkown
HY-109582	ADT-OH	Inducer	99.06%	Unkown
HY-132203	Necrostatin-34	Inhibitor	98.90%	Unkown
HY-148454	Necroptosis-IN-3	Inhibitor	99.77%	Unkown
HY-119369	FadD32 Inhibitor-1	Inhibitor	/	Unkown
HY-RS04665	FADD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-168770	Cl-Necrostatin-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fadd	NCBI	NCBI:8772

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