SLC28A3 - solute carrier family 28 member 3 Gene

Homo sapiens

Also known as CNT3

Gene ID: 64078 | Gene type: protein coding

About SLC28A3

Cytogenetic location: 9q21.32-q21.33 Genomic coordinates (GRCh38): 9:84,275,457-84,368,727 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 2 paralogues. Biased expression in gall bladder (RPKM 4.2), bone marrow (RPKM 3.2) and 11 other tissues.

Summary

Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

SLC28A3 Products(2)

mRNA	Protein	Name
NM_001199633.2	NP_001186562.1	solute carrier family 28 member 3
NM_022127.3	NP_071410.1	solute carrier family 28 member 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26481311	GOA
enables uridine transmembrane transporter activity	IDA IDA: Inferred from direct assay	22492015	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleoside transmembrane transport	IDA IDA: Inferred from direct assay	22492015	GOA
involved in pyrimidine-containing compound transmembrane transport	IDA IDA: Inferred from direct assay	22492015	GOA
involved in uridine transmembrane transport	IDA IDA: Inferred from direct assay	22492015	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC28A3 Protein Structure

Nucleos_tra2_N

Gate

Nucleos_tra2_C

0
200
400
600
691 a.a.

Protein Preferred Names

Protein Names

solute carrier family 28 member 3

concentrative Na(+)-nucleoside cotransporter 3

SLC28A3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC28A3	Q9HAS3	LGALS4	Homo sapiens	P56470	Pull Down	26481311
Intra	SLC28A3	Q9HAS3	LGALS4	Homo sapiens	P56470	Confocal	26481311
Intra	SLC28A3	Q9HAS3	LGALS4	Homo sapiens	P56470	Anti Bait CoIP	26481311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13152	SLC28A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC28A3	RGD	RGD:621224
Macaca mulatta	SLC28A3	VGNC	VGNC:77493
Bos taurus	SLC28A3	VGNC	VGNC:34793
Mus musculus	SLC28A3	MGD	MGI:2137361
Felis catus	SLC28A3	VGNC	VGNC:65295

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