MOAP1 - modulator of apoptosis 1 Gene

Homo sapiens

Also known as MAP-1; PNMA4

Gene ID: 64112 | Gene type: protein coding

About MOAP1

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:93,182,199-93,184,897 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 565 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 65.7), heart (RPKM 21.0) and 24 other tissues.

Summary

The protein encoded by this gene was identified by its interaction with Apoptosis regulator Bax protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with Bax. When overexpressed, this gene has been shown to mediate caspase-dependent Apoptosis. [provided by RefSeq, Jul 2008]

MOAP1 Products(1)

mRNA	Protein	Name
NM_022151.5	NP_071434.2	modulator of apoptosis 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11060313	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19100260	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11060313	GOA
involved in extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	16199525	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	16199525	GOA
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	16199525	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15949439	GOA
involved in positive regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	33783314	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	16199525	GOA
involved in protein insertion into mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	16199525	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19100260	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	16199525	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	19100260	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOAP1 Protein Structure

PNMA

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

modulator of apoptosis 1

MAP1

MOAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MOAP1	Q96BY2	PNMA5	Homo sapiens	Q96PV4	Y2H Array	25416956
Intra	MOAP1	Q96BY2	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
Intra	MOAP1	Q96BY2	LATS1	Homo sapiens	Q6PJG3	Y2H Array	25416956
Intra	MOAP1	Q96BY2	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	MOAP1	Q96BY2	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	MOAP1	Q96BY2	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	MOAP1	Q96BY2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	MOAP1	Q96BY2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	MOAP1	Q96BY2	THOC1	Homo sapiens	Q96FV9	Validated Y2H	32296183
Intra	MOAP1	Q96BY2	THOC1	Homo sapiens	Q96FV9	Y2H Prey Pooling	32296183
Intra	MOAP1	Q96BY2	THOC1	Homo sapiens	Q96FV9	Y2H Array	32296183
Intra	MOAP1	Q96BY2	PPP2R3C	Homo sapiens	Q969Q6	Y2H Prey Pooling	32296183
Intra	MOAP1	Q96BY2	PPP2R3C	Homo sapiens	Q969Q6	Y2H Array	32296183
Intra	MOAP1	Q96BY2	CAMK2D	Homo sapiens	Q13557	Validated Y2H	25416956
Intra	MOAP1	Q96BY2	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	MOAP1	Q96BY2	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	MOAP1	Q96BY2	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	MOAP1	Q96BY2	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	MOAP1	Q96BY2	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	MOAP1	Q96BY2	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08572	MOAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MOAP1	MGD	MGI:1915555
Rattus norvegicus	MOAP1	RGD	RGD:1307230
Felis catus	MOAP1	VGNC	VGNC:104513
Macaca mulatta	MOAP1	VGNC	VGNC:84392

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