THOC1 - THO complex subunit 1 Gene

Homo sapiens

Also known as P84; HPR1; P84N5

Gene ID: 9984 | Gene type: protein coding

About THOC1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:214,520-268,047 (from NCBI)

This gene has 19 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 6.7), bone marrow (RPKM 6.1) and 25 other tissues.

Summary

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

THOC1 Products(1)

mRNA	Protein	Name
NM_005131.3	NP_005122.2	THO complex subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15870275	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	22144908	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of THO complex	IDA IDA: Inferred from direct assay	15998806	GOA
part of THO complex part of transcription export complex	IDA IDA: Inferred from direct assay	15998806	GOA
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15358532	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15358532	GOA
part of transcription export complex	IDA IDA: Inferred from direct assay	15833825	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOC1 Protein Structure

efThoc1

Death

0
200
400
600
657 a.a.

Protein Preferred Names

Protein Names

THO complex subunit 1

THO complex 1

THOC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	THOC1	Q96FV9	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	THOC1	Q96FV9	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	THOC1	Q96FV9	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	AKAP9	Homo sapiens	Q6PJH3	Y2H Array	32296183
Intra	THOC1	Q96FV9	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	THOC1	Q96FV9	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	THOC1	Q96FV9	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	THOC1	Q96FV9	THOC5	Homo sapiens	Q13769	Anti Bait CoIP	23299939
Intra	THOC1	Q96FV9	THOC5	Homo sapiens	Q13769	Anti Tag CoIP	26496610
Intra	THOC1	Q96FV9	THOC5	Homo sapiens	Q13769	Y2H	22365833
Intra	THOC1	Q96FV9	THOC5	Homo sapiens	Q13769	Anti Tag CoIP	28514442
Intra	THOC1	Q96FV9	THOC5	Homo sapiens	Q13769	Anti Tag CoIP	33961781
Intra	THOC1	Q96FV9	THOC5	Homo sapiens	Q13769	IF	19165146
Intra	THOC1	Q96FV9	THOC5	Homo sapiens	Q13769	Anti Bait CoIP	19165146
Intra	THOC1	Q96FV9	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	THOC1	Q96FV9	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	THOC1	Q96FV9	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Array	32296183
Intra	THOC1	Q96FV9	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	PPP1R12C	Homo sapiens	Q9BZL4	Validated Y2H	32296183
Intra	THOC1	Q96FV9	MOAP1	Homo sapiens	Q96BY2	Y2H Array	25416956
Intra	THOC1	Q96FV9	MOAP1	Homo sapiens	Q96BY2	Validated Y2H	25416956
Intra	THOC1	Q96FV9	MOAP1	Homo sapiens	Q96BY2	Y2H Array	31515488
Intra	THOC1	Q96FV9	MOAP1	Homo sapiens	Q96BY2	Y2H Prey Pooling	25416956
Intra	THOC1	Q96FV9	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	THOC1	Q96FV9	TADA2A	Homo sapiens	O75478	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	TADA2A	Homo sapiens	O75478	Y2H Array	32296183
Intra	THOC1	Q96FV9	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	THOC1	Q96FV9	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	MAGEB4	Homo sapiens	O15481	Y2H Array	32296183
Intra	THOC1	Q96FV9	MAGEB4	Homo sapiens	O15481	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	RABGEF1	Homo sapiens	Q9UJ41	Y2H Prey Pooling	25416956
Intra	THOC1	Q96FV9	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	32296183
Intra	THOC1	Q96FV9	EXOC5	Homo sapiens	O00471	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14491	THOC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	THOC1	VGNC	VGNC:79175
Canis familiaris	THOC1	VGNC	VGNC:47348
Bos taurus	THOC1	VGNC	VGNC:35840
Mus musculus	THOC1	MGD	MGI:1919668
Felis catus	THOC1	VGNC	VGNC:66166
Rattus norvegicus	THOC1	RGD	RGD:1308657

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