2. Gene
  3. SLC10A1 - solute carrier family 10 member 1 Gene

SLC10A1 - solute carrier family 10 member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NTCP; FHCA2

Gene ID: 6554 | Gene type: protein coding

About SLC10A1

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,775,416-69,797,241 (from NCBI)

This gene has 1 transcript (splice variant), 265 orthologues, 5 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 124.7).

Summary

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of Cholesterol metabolism, hence this protein is important for Cholesterol homeostasis. [provided by RefSeq, Oct 2011]

SLC10A1 Products(1)

mRNA Protein Name
NM_003049.4 NP_003040.1 hepatic sodium/bile acid cotransporter
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC10A1 Protein Structure

SBF

SBF: Sodium Bile acid symporter family (33 - 212)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
Protein Preferred Names Protein Names

hepatic sodium/bile acid cotransporter

Na(+)/bile acid cotransporter

SLC10A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC10A1 Q14973 SLC25A46 Homo sapiens Q96AG3
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 NINJ2 Homo sapiens Q9NZG7
Validated Y2H
32296183
Intra
SLC10A1 Q14973 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TOMM6 Homo sapiens Q96B49
Validated Y2H
32296183
Intra
SLC10A1 Q14973 ORMDL2 Homo sapiens Q53FV1
Validated Y2H
32296183
Intra
SLC10A1 Q14973 FA2H Homo sapiens Q7L5A8
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TVP23B Homo sapiens Q9NYZ1
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMEM239 Homo sapiens Q8WW34-2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 CFHR5 Homo sapiens Q9BXR6
Validated Y2H
32296183
Intra
SLC10A1 Q14973 GPR151 Homo sapiens Q8TDV0
Validated Y2H
32296183
Intra
SLC10A1 Q14973 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMEM121 Homo sapiens Q9BTD3
Validated Y2H
32296183
Intra
SLC10A1 Q14973 IFITM2 Homo sapiens Q6IBB0
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC16A13 Homo sapiens Q7RTY0
Validated Y2H
32296183
Intra
SLC10A1 Q14973 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 PKMYT1 Homo sapiens Q99640-2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra
SLC10A1 Q14973 DGAT2L6 Homo sapiens Q6ZPD8
Validated Y2H
32296183
Intra
SLC10A1 Q14973 OTOP3 Homo sapiens Q7RTS5
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC12A7 Homo sapiens Q9Y666-2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC35E4 Homo sapiens Q6ICL7
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC7A3 Homo sapiens Q8WY07
Validated Y2H
32296183
Intra
SLC10A1 Q14973 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 AGPAT3 Homo sapiens Q9NRZ7
Validated Y2H
32296183
Intra
SLC10A1 Q14973 ARL6IP6 Homo sapiens Q8N6S5
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMUB2 Homo sapiens Q71RG4
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMBIM1 Homo sapiens Q969X1
Validated Y2H
32296183
Intra
SLC10A1 Q14973 LRP10 Homo sapiens Q7Z4F1
Validated Y2H
32296183
Intra
SLC10A1 Q14973 GDE1 Homo sapiens Q9NZC3
Validated Y2H
32296183
Intra
SLC10A1 Q14973 COX20 Homo sapiens Q5RI15
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SFT2D1 Homo sapiens Q8WV19
Validated Y2H
32296183
Intra
SLC10A1 Q14973 q96fb2_human Homo sapiens Q96FB2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 MFSD6 Homo sapiens Q6ZSS7
Validated Y2H
32296183
Intra
SLC10A1 Q14973 ACSL5 Homo sapiens Q9ULC5
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMEM222 Homo sapiens Q9H0R3
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SFXN1 Homo sapiens Q9H9B4
Validated Y2H
32296183
Intra
SLC10A1 Q14973 ATP6V0B Homo sapiens Q99437
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC66A2 Homo sapiens Q8N2U9
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SACM1L Homo sapiens Q9NTJ5
Validated Y2H
32296183
Intra
SLC10A1 Q14973 DERL1 Homo sapiens Q9BUN8
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SCAMP4 Homo sapiens Q969E2
Validated Y2H
32296183
Intra
SLC10A1 Q14973 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra
SLC10A1 Q14973 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
SLC10A1 Q14973 NEU1 Homo sapiens Q99519
Validated Y2H
32296183
Intra
SLC10A1 Q14973 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
Intra
SLC10A1 Q14973 VAMP3 Homo sapiens Q15836
Validated Y2H
32296183
Intra
SLC10A1 Q14973 CMTM3 Homo sapiens Q96MX0
Validated Y2H
32296183
Intra
SLC10A1 Q14973 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra
SLC10A1 Q14973 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
Intra
SLC10A1 Q14973 UNC50 Homo sapiens Q53HI1
Validated Y2H
32296183
Intra
SLC10A1 Q14973 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra
SLC10A1 Q14973 TMEM234 Homo sapiens Q8WY98
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra
SLC10A1 Q14973 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Intra
SLC10A1 Q14973 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypercholanemia, Familial, 2

FHCA2

Ntcp Deficiency

Hypercholanemia, Familial 2

Ntcpd
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Biliary Atresia

Congenital Biliary Atresia

Isolated Biliary Atresia

Isolated Atresia Of Bile Ducts

Non-Syndromic Biliary Atresia

Atresia Of Bile Duct

Biliary Atresia, Congenital

Atresia Of Bile Ducts

Bile Duct Atresia

Congenital Bile Duct Atresia

Ba - [Biliary Atresia]

Impervious Bile Duct

Atresia Of Common Duct

Biliary Duct Atresia

Bile Ductal Atresia

Cystic Duct Atresia
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Hepatoblastoma
Cholestasis, Benign Recurrent Intrahepatic, 1

Benign Recurrent Intrahepatic Cholestasis

BRIC1

Summerskill Syndrome

Bric

Summerskill-Walshe-Tygstrup Syndrome

Cholestasis, Benign Recurrent Intrahepatic

Benign Recurrent Intrahepatic Cholestasis 1

Benign Recurrent Intrahepatic Cholestasis Type 1

Bric Type 1

Low Gamma-Gt Familial Intrahepatic Cholestasis

Recurrent Familial Intrahepatic Cholestasis

Cholestasis, Benign Recurrent Intrahepatic 1

Mild Atp8b1 Deficiency

Recurrent Familial Intrahepatic Cholestasis 1

Abcb11-Related Intrahepatic Cholestasis

Atp8b1-Related Intrahepatic Cholestasis

Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

Progressive Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic 3

Bric - [Benign Recurrent Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 2

PFIC2

Cholestasis, Progressive Familial Intrahepatic 2

Progressive Familial Intrahepatic Cholestasis Type 2

Progressive Familial Intrahepatic Cholestasis 2

Bsep Deficiency

Recurrent Familial Intrahepatic Cholestasis 2

Benign Recurrent Intrahepatic Cholestasis 2

Severe Abcb11 Deficiency

Bric2

Cholestasis, Benign Recurrent Intrahepatic 2

Mild Abcb11 Deficiency

Cholestasis, Intrahepatic, Familial, Progressive, Type 2
Bile Acid Synthesis Defect, Congenital, 2

Cholestasis With Delta(4)-3-Oxosteroid 5-Beta-Reductase Deficiency

CBAS2

Congenital Bile Acid Synthesis Defect 2

Congenital Bile Acid Synthesis Defect Type 2

Congenital Bile Acid Synthesis Defect, Type 2

Basd2

Bile Acid Synthesis Defect, Congenital, Type 2
Pericholangitis
Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy

Gravidic Intrahepatic Cholestasis

Pregnancy-Related Cholestasis

Icp

Pregnancy Related Cholestasis

Cholestasis, Intrahepatic Of Pregnancy

Familial Intrahepatic Cholestasis Of Pregnancy

Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

Ricp

Obstetric Cholestasis
Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure
Hepatitis D

Delta Hepatitis

Hepatitis Delta

Hdv

Hepatitis D Virus

Hepatitis D Infection
Progressive Familial Intrahepatic Cholestasis

Abcb4-Related Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic

Pfic

Byler Disease

Abcb11-Related Intrahepatic Cholestasis

Atp8b1-Related Intrahepatic Cholestasis

Bsep Deficiency

Byler Disease

Byler Syndrome

Fic1 Deficiency

Low Γ-Gt Familial Intrahepatic Cholestasis

Mdr3 Deficiency

Pfic

Cholestasis, Intrahepatic, Familial, Progressive

Pfic - [Progressive Familial Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 3

PFIC3

Cholestasis, Progressive Familial Intrahepatic 3

Mdr3 Deficiency

Progressive Familial Intrahepatic Cholestasis Type 3

Progressive Familial Intrahepatic Cholestasis 3

Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gamma-Glutamyltransferase

Cholestasis, Progressive Familial Intrahepatic, With Elevated Serum Gamma-Glutamyltransferase

Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gama-Glutamyltransferase

Cholestasis, Intrahepatic, Familial, Progressive, Type 3
Extrahepatic Cholestasis

Cholestasis, Extrahepatic

Extrahepatic Biliary Stasis

Extrahepatic Obstructive Biliary Disease

Cholestasis Extrahepatic
Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash
Cholestasis, Progressive Familial Intrahepatic, 1

PFIC1

Byler Disease

Cholestasis, Progressive Familial Intrahepatic 1

Progressive Familial Intrahepatic Cholestasis 1

Progressive Familial Intrahepatic Cholestasis Type 1

Fic1 Deficiency

Byler'S Disease

Cholestasis, Fatal Intrahepatic

Progressive Familial Intrahepatic Cholestasis

Severe Atp8b1 Deficiency

Fatal Intrahepatic Cholestasis

Cholestasis, Intrahepatic, Familial, Progressive, Type 1

Progressive Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic 3
Hard Palate Cancer

Malignant Neoplasm Of Hard Palate

Malignant Tumor Of Hard Palate

Malignant Tumour Of Hard Palate
Bile Duct Disease

Bile Duct Diseases

Bile Duct Disorder

Disorder Of Bile Duct
Biliary Tract Disease

Biliary Tract Diseases

Biliary Tract Abnormality
Sclerosing Cholangitis

Fibrosing Cholangitis

Cholangitis, Sclerosing

Primary Sclerosing Cholangitis
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12985 SLC10A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC10A1 VGNC VGNC:65180
Bos taurus SLC10A1 VGNC VGNC:34659
Canis familiaris SLC10A1 VGNC VGNC:46211
Rattus norvegicus SLC10A1 RGD RGD:3681
Macaca mulatta SLC10A1 VGNC VGNC:77380
Mus musculus SLC10A1 MGD MGI:97379