2. Gene
  3. VSIR - V-set immunoregulatory receptor Gene

VSIR - V-set immunoregulatory receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha

Gene ID: 64115 | Gene type: protein coding

About VSIR

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:71,747,556-71,773,520 (from NCBI)

This gene has 3 transcripts (splice variants), 482 orthologues and 14 paralogues. Broad expression in spleen (RPKM 39.2), bone marrow (RPKM 38.8) and 23 other tissues.

Summary

Enables endopeptidase activator activity; Enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

VSIR Products(1)

mRNA Protein Name
NM_022153.2 NP_071436.1 V-type immunoglobulin domain-containing suppressor of T-cell activation precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activator activity IDA
IDA: Inferred from direct assay
20666777 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
20666777 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26228159 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
24691993 GOA
involved in negative regulation of CD8-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
24691993 GOA
involved in negative regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
24691993 GOA
involved in negative regulation of interleukin-17 production IDA
IDA: Inferred from direct assay
24691993 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
24691993 GOA
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
24691993 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
20666777 GOA
involved in positive regulation of collagen catabolic process IDA
IDA: Inferred from direct assay
20666777 GOA
involved in positive regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
20666777 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20666777 GOA
involved in positive regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
24691993 GOA
involved in zymogen activation IDA
IDA: Inferred from direct assay
20666777 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20666777 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSIR Protein Structure

V-set

V-set: Immunoglobulin V-set domain (43 - 150)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

V-type immunoglobulin domain-containing suppressor of T-cell activation

Death Domain1alpha

VSIR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VSIR Q9H7M9 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
Intra
VSIR Q9H7M9 VSIR Homo sapiens Q9H7M9
Pull Down
26228159
Intra
VSIR Q9H7M9 VSIR Homo sapiens Q9H7M9
Anti Tag CoIP
26228159
Intra
VSIR Q9H7M9 VSIR Homo sapiens Q9H7M9
Crosslink
26228159
Intra
VSIR Q9H7M9 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
VSIR Q9H7M9 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
Intra
VSIR Q9H7M9 DOLK Homo sapiens Q9UPQ8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VSIR Proteins

Cat. No. Product Name Accession Purity
HY-P70983 VISTA/B7-H5 Protein, Human (HEK293, His) AAH20568.1 (F33-A194) ≥95%
HY-P77879 VISTA/B7-H5 Protein, Human (HEK293, Fc) Q9H7M9 (F33-A194) ≥95%
HY-P78936 VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) Q9H7M9 (F33-A194) ≥95%

Related Diseases

Diseases Alias
Hard Palate Cancer

Malignant Neoplasm Of Hard Palate

Malignant Tumor Of Hard Palate

Malignant Tumour Of Hard Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15711 VSIR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta VSIR VGNC VGNC:79834
Canis familiaris VSIR VGNC VGNC:51998
Bos taurus VSIR VGNC VGNC:50150
Rattus norvegicus VSIR RGD RGD:1590938
Felis catus VSIR VGNC VGNC:66980
Mus musculus VSIR MGD MGI:1921298
Others VSIR NCBI