2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. VISTA

VISTA

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V-domain immunoglobulin suppressor of T cell activation (VISTA, also known as DD1α, Gi24, Dies1, SISP1, C10orf54, PD-1H and B7-H5) is a negative immune checkpoint regulator that belongs to the B7-CD28 family. VISTA is highly expressed on hematopoietic cells, with the greatest densities in myeloid and granulocytic cells, and weaker expression on cluster of differentiation CD 4+ and CD8+ T cells. VISTA is a type I transmembrane protein with an extracellular IgV domain, a stalk region, a transmembrane segment, and a cytoplasmic tail. VISTA acts as inhibitory receptor on T cells, and also functions as a ligand when expressed on antigen-presenting cells (APCs). It regulates innate and adaptive anti-tumoral immune responses substantially.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P77879
    VISTA/B7-H5 Protein, Human (HEK293, Fc)

    B7H5; B7-H5; VISTA; VSIR ; PD1H; PD-1H; 4632428N05Rik; C10orf54; Dies1; Gi24; PP2135; SISP1

    		Human HEK293
    VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (HEK293, Fc) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Human (HEK293, Fc) is 162 a.a., with molecular weight of 70-80 kDa.
  • HY-P72428
    VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His)

    V-type immunoglobulin domain-containing suppressor of T-cell activation; Vsir; Dies1; PD-1H; VISTA

    		Mouse HEK293
    VISTA/B7-H5 Protein is a type I transmembrane protein expressed primarily in white blood cells that inhibits T cell function. VISTA/B7-H5 Protein promotes embryonic stem cell differentiation by inhibiting BMP4 signaling and stimulates MMP14 mediated MMP2 activation. VISTA/B7-H5 Protein is highly expressed in tumors. VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) is the recombinant mouse-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) is 159 a.a., with molecular weight of 30-40 kDa.
  • HY-P73547
    VISTA/B7-H5 Protein, Mouse (HEK293, Fc)

    Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Mouse HEK293
    VISTA/B7-H5 Protein is a type I transmembrane protein expressed primarily in white blood cells that inhibits T cell function. VISTA/B7-H5 Protein promotes embryonic stem cell differentiation by inhibiting BMP4 signaling and stimulates MMP14 mediated MMP2 activation. VISTA/B7-H5 Protein is highly expressed in tumors. VISTA/B7-H5 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P78936
    VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi)

    Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Human HEK293
    VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) is 162 a.a., with molecular weight of 36-47 kDa.
  • HY-P70983
    VISTA/B7-H5 Protein, Human (HEK293, His)

    VISTA; B7-H5; Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Human HEK293
    VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Human (HEK293, His) is the recombinant human-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P73544
    VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His)

    Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Rhesus Macaque HEK293
    VISTA/B7-H5 protein is an immune regulatory receptor that can inhibit the activation of T cells and regulate immune responses as a ligand and receptor. VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-His labeled tag. The total length of VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, His) is 162 a.a., with molecular weight of ~19.6 kDa.
  • HY-P73546
    VISTA/B7-H5 Protein, Rat (HEK293, Fc)

    Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Rat HEK293
    VISTA/B7-H5 protein, an immunoregulatory receptor, inhibits T-cell response and may regulate embryonic stem cell differentiation by inhibiting BMP4 signaling. It also stimulates MMP14-mediated MMP2 activation, suggesting a role in matrix metalloproteinase processes. These roles highlight the significance of VISTA/B7-H5 in immune regulation, embryonic development, and extracellular matrix dynamics. VISTA/B7-H5 Protein, Rat (HEK293, Fc) is the recombinant rat-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Rat (HEK293, Fc) is 159 a.a., with molecular weight of ~44.7 kDa.
  • HY-P73482
    VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc)

    Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Cynomolgus HEK293
    VISTA/B7-H5 Protein is a B7 family member that maintains T cell and myeloid quiescence and is a promising target for combination cancer immunotherapy. VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells. VISTA inhibits T cell activation, proliferation, and cytokine production. VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Cynomolgus (HEK293, Fc) is 162 a.a., with molecular weight of ~44.9 kDa.
  • HY-P70962
    VISTA/B7-H5 Protein, Cynomolgus (HEK293, His)

    Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Cynomolgus HEK293
    VISTA/B7-H5 Protein is a B7 family member that maintains T cell and myeloid quiescence and is a promising target for combination cancer immunotherapy. VISTA not only acts as a ligand expressed on antigenpresenting cells, but also functions as a receptor on T cells. VISTA inhibits T cell activation, proliferation, and cytokine production. VISTA/B7-H5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VISTA/B7-H5 Protein, Cynomolgus (HEK293, His) is 162 a.a., with molecular weight of 30-50 kDa.
  • HY-P73545
    VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc)

    Platelet receptor Gi24; Stress-induced secreted protein-1; Sisp-1; C10orf54; SISP1

    		Rhesus Macaque HEK293
    VISTA/B7-H5 protein is an immune regulatory receptor that can inhibit the activation of T cells and regulate immune responses as a ligand and receptor. VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived VISTA/B7-H5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VISTA/B7-H5 Protein, Rhesus Macaque (HEK293, Fc) is 194 a.a., with molecular weight of ~44.9 kDa.
Cat. No. Product Name Effect Purity