ECSCR - endothelial cell surface expressed chemotaxis and apoptosis regulator Gene

Homo sapiens

Also known as ARIA; ECSM2

Gene ID: 641700 | Gene type: protein coding

About ECSCR

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,448,560-139,462,743 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele and 92 orthologues. Broad expression in placenta (RPKM 24.9), lung (RPKM 23.6) and 22 other tissues.

Summary

The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ECSCR Products(2)

mRNA	Protein	Name
NM_001077693.4	NP_001071161.1	endothelial cell-specific chemotaxis regulator isoform 1 precursor
NM_001293739.2	NP_001280668.1	endothelial cell-specific chemotaxis regulator isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19416853	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19416853	GOA
acts upstream of or within positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19416853	GOA
acts upstream of or within positive regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	19416853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19416853	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19416853	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endothelial cell-specific chemotaxis regulator

apoptosis regulator through modulating IAP expression

ECSCR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ECSCR	Q19T08	PTEN	Homo sapiens	P60484-1	BiFC	21593423
Intra	ECSCR	Q19T08	PTEN	Homo sapiens	P60484-1	Anti Tag CoIP	21593423
Intra	ECSCR	Q19T08	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	19416853
Intra	ECSCR	Q19T08	PSMA7	Homo sapiens	O14818	Y2H	19416853

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ECSCR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77919	ECSCR Protein, Human (HEK293, Fc)	Q19T08 (Q25-A124)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04147	ECSCR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ECSCR	RGD	RGD:1594804
Mus musculus	ECSCR	MGD	MGI:1915795

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