MLST8 - MTOR associated protein, LST8 homolog Gene

Homo sapiens

Also known as GBL; LST8; POP3; WAT1; GbetaL

Gene ID: 64223 | Gene type: protein coding

About MLST8

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,205,454-2,209,453 (from NCBI)

This gene has 35 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 10.4), brain (RPKM 8.7) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin Cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]

MLST8 Products(7)

mRNA	Protein	Name
NM_001199173.3	NP_001186102.1	target of rapamycin complex subunit LST8 isoform a
NM_001199174.3	NP_001186103.1	target of rapamycin complex subunit LST8 isoform a
NM_001199175.3	NP_001186104.1	target of rapamycin complex subunit LST8 isoform b
NM_001352057.2	NP_001338986.1	target of rapamycin complex subunit LST8 isoform c
NM_001352059.2	NP_001338988.1	target of rapamycin complex subunit LST8 isoform d
NM_001352060.2	NP_001338989.1	target of rapamycin complex subunit LST8 isoform d
NM_022372.6	NP_071767.3	target of rapamycin complex subunit LST8 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12408816	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	12718876	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in TORC1 signaling	IMP IMP: Inferred from mutant phenotype	12718876	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	15467718	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15467718	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TORC1 complex	IDA IDA: Inferred from direct assay	12718876	GOA
part of TORC1 complex	IPI IPI: Inferred from physical interaction	26678875	GOA
part of TORC2 complex	IDA IDA: Inferred from direct assay	24036451	GOA
part of TORC2 complex	IPI IPI: Inferred from physical interaction	17461779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLST8 Protein Structure

WD40

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

target of rapamycin complex subunit LST8

TORC subunit LST8

MLST8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MLST8	Q9BVC4	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	20562859
Intra	MLST8	Q9BVC4	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	12408816
Intra	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	12408816
Intra	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	20562859
Intra	MLST8	Q9BVC4	MTOR	Homo sapiens	P42345	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Subependymal Glioma

Mixed Subependymoma-Ependymoma	Subependymal Astrocytoma
Who Grade I Ependymal Tumor	Glioma, Subependymal

Kidney Angiomyolipoma

Angiomyolipoma Of Kidney

Renal Angiomyolipoma

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy	Severe Myoclonic Epilepsy In Infancy
Smei	Epileptic Encephalopathy, Early Infantile, 6
DRVT	Developmental And Epileptic Encephalopathy 6a
Dee6a	Eiee6
Developmental And Epileptic Encephalopathy, 6	Dee6
Developmental And Epileptic Encephalopathy 6	Early Infantile Epileptic Encephalopathy 6
Myoclonic Epilepsy, Severe, Of Infancy	Sme
Severe Myoclonus Epilepsy Of Infancy	Borderline Smei
Smeb	Smeb-M
Smeb-O	Smeb-Sw
Smei-Borderland	Smei-Borderland More Than One Feature
Smei-Borderland-Myoclonic Seizures	Smei-Borderland-Spike Wave
Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures	ICEGTC
Infantile Severe Myoclonic Epilepsy	Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Subependymal Giant Cell Astrocytoma

Sega	Astrocytoma Subependymal Giant Cell
Subependymal Giant-Cell Astrocytoma

Benign Ependymoma

Ependymoma	Epithelial Ependymoma
Who Grade Ii Ependymal Tumor	Myxopapillary Ependymoma

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08502	MLST8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MLST8	VGNC	VGNC:74820
Mus musculus	MLST8	MGD	MGI:1929514
Rattus norvegicus	MLST8	RGD	RGD:69242
Felis catus	MLST8	VGNC	VGNC:63527
Bos taurus	MLST8	VGNC	VGNC:31507
Canis familiaris	MLST8	VGNC	VGNC:43266
Others	MLST8	NCBI

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