1. Gene
  2. PDLIM2 - PDZ and LIM domain 2 Gene

PDLIM2 - PDZ and LIM domain 2 Gene

Homo sapiens

Also known as SLIM; MYSTIQUE

Gene ID: 64236 | Gene type: protein coding

About PDLIM2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,578,741-22,598,026 (from NCBI)

This gene has 20 transcripts (splice variants), 201 orthologues and 7 paralogues. Broad expression in spleen (RPKM 22.4), lung (RPKM 9.5) and 21 other tissues.

Summary

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin Cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast Cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

PDLIM2 Products(4)

mRNA Protein Name
NM_001368120.1 NP_001355049.1 PDZ and LIM domain protein 2 isoform 4
NM_021630.6 NP_067643.3 PDZ and LIM domain protein 2 isoform 2
NM_176871.5 NP_789847.1 PDZ and LIM domain protein 2 isoform 1
NM_198042.4 NP_932159.1 PDZ and LIM domain protein 2 isoform 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDLIM2 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (9 - 79)

LIM

LIM: LIM domain (286 - 337)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

PDZ and LIM domain protein 2

PDLIM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PDLIM2 Q96JY6 ACD Homo sapiens Q96AP0 21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PDLIM2 VGNC VGNC:44384
Macaca mulatta PDLIM2 VGNC VGNC:82203
Felis catus PDLIM2 VGNC VGNC:78547
Bos taurus PDLIM2 VGNC VGNC:32708
Mus musculus PDLIM2 MGD MGI:2384850
Rattus norvegicus PDLIM2 RGD RGD:1359203