COP1 - COP1 E3 ubiquitin ligase Gene

Homo sapiens

Also known as FAP78; RFWD2; CFAP78; RNF200

Gene ID: 64326 | Gene type: protein coding

About COP1

Cytogenetic location: 1q25.1-q25.2 Genomic coordinates (GRCh38): 1:175,944,831-176,207,286 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 5.8), colon (RPKM 4.2) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Part of Cul4A-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

COP1 Products(3)

mRNA	Protein	Name
NM_001001740.4	NP_001001740.1	E3 ubiquitin-protein ligase COP1 isoform b
NM_001286644.2	NP_001273573.1	E3 ubiquitin-protein ligase COP1 isoform c precursor
NM_022457.7	NP_071902.2	E3 ubiquitin-protein ligase COP1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14739464	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	19805145	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19805145	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	14739464	GOA
involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	19805145	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul4A-RING E3 ubiquitin ligase complex	IDA IDA: Inferred from direct assay	14739464	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COP1 Protein Structure

zf-C3HC4

WD40

0
200
400
600
731 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase COP1

E3 ubiquitin-protein ligase RFWD2

COP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COP1	Q8NHY2	ETV1	Homo sapiens	P50549	Anti Tag CoIP	33961781
Intra	COP1	Q8NHY2	ETV1	Homo sapiens	P50549	Anti Bait CoIP	21572435
Intra	COP1	Q8NHY2	ETV5	Homo sapiens	P41161	Anti Tag CoIP	33961781
Intra	COP1	Q8NHY2	SFN	Homo sapiens	P31947	Anti Tag CoIP	20843328
Intra	COP1	Q8NHY2	COPS6	Homo sapiens	Q7L5N1	Anti Bait CoIP	21625211
Intra	COP1	Q8NHY2	ETS1	Homo sapiens	P14921-1	Anti Tag CoIP	25117710

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157416	COP1-ATGL modulator 1	Activator	99.31%	Unkown
HY-RS03020	COP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	COP1	VGNC	VGNC:106344
Mus musculus	COP1	MGD	MGI:1347046
Canis familiaris	COP1	VGNC	VGNC:53338
Felis catus	COP1	VGNC	VGNC:97388
Bos taurus	COP1	VGNC	VGNC:50041
Rattus norvegicus	COP1	RGD	RGD:1304773

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