ARHGAP9 - Rho GTPase activating protein 9 Gene

Homo sapiens

Also known as 10C; RGL1

Gene ID: 64333 | Gene type: protein coding

About ARHGAP9

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,472,269-57,488,824 (from NCBI)

This gene has 24 transcripts (splice variants), 198 orthologues and 3 paralogues. Broad expression in spleen (RPKM 23.2), bone marrow (RPKM 22.4) and 14 other tissues.

Summary

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP9 Products(11)

mRNA	Protein	Name
NM_001080156.3	NP_001073625.1	rho GTPase-activating protein 9 isoform 3
NM_001080157.2	NP_001073626.1	rho GTPase-activating protein 9 isoform 2
NM_001319850.2	NP_001306779.2	rho GTPase-activating protein 9 isoform 4
NM_001319851.2	NP_001306780.1	rho GTPase-activating protein 9 isoform 5
NM_001319852.2	NP_001306781.1	rho GTPase-activating protein 9 isoform 6
NM_001367422.1	NP_001354351.1	rho GTPase-activating protein 9 isoform 7
NM_001367423.1	NP_001354352.1	rho GTPase-activating protein 9 isoform 8
NM_001367424.1	NP_001354353.1	rho GTPase-activating protein 9 isoform 9
NM_001367425.1	NP_001354354.1	rho GTPase-activating protein 9 isoform 10
NM_001367426.1	NP_001354355.1	rho GTPase-activating protein 9 isoform 3
NM_032496.4	NP_115885.2	rho GTPase-activating protein 9 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	11396949	GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	17339315	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP9 Protein Structure

SH3_1

RhoGAP

0
200
400
600
731 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 9

rho-type GTPase-activating protein 9

ARHGAP9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARHGAP9	Q9BRR9	GOLGA6A	Homo sapiens	Q9NYA3	Validated Y2H	32296183
Intra	ARHGAP9	Q9BRR9	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Array	32296183
Intra	ARHGAP9	Q9BRR9	GOLGA6A	Homo sapiens	Q9NYA3	Y2H Prey Pooling	32296183
Intra	ARHGAP9	Q9BRR9	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ARHGAP9	Q9BRR9	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ARHGAP9	Q9BRR9	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	ARHGAP9	Q9BRR9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	ARHGAP9	Q9BRR9	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	ARHGAP9	Q9BRR9	FHL2	Homo sapiens	Q14192	Y2H Array	25416956
Intra	ARHGAP9	Q9BRR9	MRPL38	Homo sapiens	Q96DV4	Y2H Prey Pooling	32296183
Intra	ARHGAP9	Q9BRR9	MRPL38	Homo sapiens	Q96DV4	Y2H Array	32296183
Intra	ARHGAP9	Q9BRR9	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Array	32296183
Intra	ARHGAP9	Q9BRR9	TSC22D4	Homo sapiens	Q9Y3Q8	Validated Y2H	32296183
Intra	ARHGAP9	Q9BRR9	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Prey Pooling	32296183
Intra	ARHGAP9	Q9BRR9	ABI3	Homo sapiens	Q9P2A4	Y2H Array	32296183
Intra	ARHGAP9	Q9BRR9	ABI3	Homo sapiens	Q9P2A4	Y2H Prey Pooling	32296183
Intra	ARHGAP9	Q9BRR9	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	ARHGAP9	Q9BRR9	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00942	ARHGAP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARHGAP9	VGNC	VGNC:69826
Rattus norvegicus	ARHGAP9	RGD	RGD:1305342
Bos taurus	ARHGAP9	VGNC	VGNC:26100
Felis catus	ARHGAP9	VGNC	VGNC:59895
Mus musculus	ARHGAP9	MGD	MGI:2143764

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