PGA4 - pepsinogen A4 Gene

Homo sapiens

Gene ID: 643847 | Gene type: protein coding

About PGA4

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,222,347-61,231,694 (from NCBI)

This gene has 8 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 23688.7).

Summary

This gene encodes a protein precursor of the digestive Enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active Enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric Cancer. [provided by RefSeq, Jul 2015]

PGA4 Products(1)

mRNA	Protein	Name
NM_001079808.6	NP_001073276.1	pepsin A-4 preproprotein

PGA4 Protein Structure

A1_Propeptide

Asp

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

pepsin A-4

pepsinogen 4, group I (pepsinogen A)

Recombinant PGA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77135	Pepsinogen A4/PGA4 Protein, Human (HEK293, Fc)	P0DJD7/NP_001073276.1 (I16-A388)	≥95%
HY-P77136	Pepsinogen A4/PGA4 Protein, Human (HEK293, His)	P0DJD7 (I16-A388)	≥95%

Related Diseases

Diseases

Alias

Atrophic Gastritis

Gastritis, Atrophic	Gastric Atrophy
Gastritis Atrophic

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland

Macular Degeneration, Age-Related, 10

ARMD10	Age Related Macular Degeneration 10
Macular Degeneration, Age-Related, Type 10

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10372	PGA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PGA4	MGD	MGI:1915935

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