2. Gene
  3. PGA4 - pepsinogen A4 Gene

PGA4 - pepsinogen A4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 643847 | Gene type: protein coding

About PGA4

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,222,347-61,231,694 (from NCBI)

This gene has 8 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 23688.7).

Summary

This gene encodes a protein precursor of the digestive Enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active Enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric Cancer. [provided by RefSeq, Jul 2015]

PGA4 Products(1)

mRNA Protein Name
NM_001079808.6 NP_001073276.1 pepsin A-4 preproprotein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGA4 Protein Structure

A1_Propeptide

A1_Propeptide: A1 Propeptide (17 - 45)

Asp

Asp: Eukaryotic aspartyl protease (75 - 386)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

pepsin A-4

pepsinogen 4, group I (pepsinogen A)

PGA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PGA4 P0DJD7 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
PGA4 P0DJD7 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
PGA4 P0DJD7 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra
PGA4 P0DJD7 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
PGA4 P0DJD7 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
PGA4 P0DJD7 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
PGA4 P0DJD7 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
PGA4 P0DJD7 FIMP Homo sapiens Q96LL3
Validated Y2H
32296183
Intra
PGA4 P0DJD7 FIMP Homo sapiens Q96LL3
Y2H Array
32296183
Intra
PGA4 P0DJD7 FIMP Homo sapiens Q96LL3
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
PGA4 P0DJD7 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
PGA4 P0DJD7 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
PGA4 P0DJD7 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
PGA4 P0DJD7 HHLA2 Homo sapiens Q9UM44
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 HHLA2 Homo sapiens Q9UM44
Validated Y2H
32296183
Intra
PGA4 P0DJD7 HHLA2 Homo sapiens Q9UM44
Y2H Array
32296183
Intra
PGA4 P0DJD7 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
PGA4 P0DJD7 PVR Homo sapiens P15151
Validated Y2H
32296183
Intra
PGA4 P0DJD7 PVR Homo sapiens P15151
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PGA4 Proteins

Cat. No. Product Name Accession Purity
HY-P77135 Pepsinogen A4/PGA4 Protein, Human (HEK293, Fc) P0DJD7/NP_001073276.1 (I16-A388) ≥95%
HY-P77136 Pepsinogen A4/PGA4 Protein, Human (HEK293, His) P0DJD7 (I16-A388) ≥95%

Related Diseases

Diseases Alias
Atrophic Gastritis

Gastritis, Atrophic

Gastric Atrophy

Gastritis Atrophic
Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux
Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland
Macular Degeneration, Age-Related, 10

ARMD10

Age Related Macular Degeneration 10

Macular Degeneration, Age-Related, Type 10
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10372 PGA4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PGA4 MGD MGI:1915935