CLRN2 - clarin 2 Gene

Homo sapiens

Also known as DFNB117

Gene ID: 645104 | Gene type: protein coding

About CLRN2

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,515,165-17,527,104 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues, 2 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene belongs to the clarin family of genes. The clarins appear to belong to a large superfamily of small integral membrane glycoproteins with four transmembrane domains. The exact function of this gene is unknown. [provided by RefSeq, Oct 2008]

CLRN2 Products(1)

mRNA	Protein	Name
NM_001079827.2	NP_001073296.1	clarin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	33496845	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLRN2 Protein Structure

PMP22_Claudin

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

clarin-2

CLRN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLRN2	A0PK11	NEMP1	Homo sapiens	O14524-2	Validated Y2H	32296183
Intra	CLRN2	A0PK11	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	CLRN2	A0PK11	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	CLRN2	A0PK11	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	LRRC25	Homo sapiens	Q8N386	Validated Y2H	32296183
Intra	CLRN2	A0PK11	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	CLRN2	A0PK11	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	CLRN2	A0PK11	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	CLRN2	A0PK11	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	CLRN2	A0PK11	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	CLRN2	A0PK11	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	CLRN2	A0PK11	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	CLRN2	A0PK11	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	CLRN2	A0PK11	CLDN5	Homo sapiens	O00501	Validated Y2H	32296183
Intra	CLRN2	A0PK11	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	CLRN2	A0PK11	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183
Intra	CLRN2	A0PK11	TEX29	Homo sapiens	Q8N6K0	Validated Y2H	32296183
Intra	CLRN2	A0PK11	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	ARL6IP6	Homo sapiens	Q8N6S5	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	ARL6IP6	Homo sapiens	Q8N6S5	Validated Y2H	32296183
Intra	CLRN2	A0PK11	ARL6IP6	Homo sapiens	Q8N6S5	Y2H Array	32296183
Intra	CLRN2	A0PK11	SIT1	Homo sapiens	Q9Y3P8	Validated Y2H	32296183
Intra	CLRN2	A0PK11	SIT1	Homo sapiens	Q9Y3P8	Y2H Array	32296183
Intra	CLRN2	A0PK11	SIT1	Homo sapiens	Q9Y3P8	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	CLRN2	A0PK11	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	CLRN2	A0PK11	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	CLRN2	A0PK11	KLRC1	Homo sapiens	P26715	Validated Y2H	32296183
Intra	CLRN2	A0PK11	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	CLRN2	A0PK11	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 117

DFNB117

Deafness, Autosomal Recessive, 117

Usher Syndrome, Type Iiia

Usher Syndrome Type 3	Ush3
Usher Syndrome Type 3a	USH3A
Usher Syndrome, Type Iii	Usher Syndrome, Type 3
Usher Syndrome, Type 3a	Usher Syndrome Type Iiia
Usher Syndrome 3a	Usher'S Syndrome Type 3
Usher Syndrome Iii	Usher Syndrome Type Iii

Acute Hemorrhagic Leukoencephalitis

Ahl	Acute Haemorrhagic Leucoencephalitis Of Weston Hurst
Leukoencephalitis, Acute Hemorrhagic	Acute Hemorrhagic Encephalomyelitis
Acute Necrotizing Hemorrhagic Leukoencephalitis	Weston-Hurst Syndrome
Ahle	Acute Haemorrhagic Leucoencephalitis
Hurst Disease	Acute Haemorrhagic Leukoencephalitis, Postimmunization Or Postvaccinal
Postimmunization Or Postvaccinal Leukoencephalopathy

Deafness, Autosomal Recessive 111

DFNB111	Autosomal Recessive Nonsyndromic Deafness 111
Autosomal Recessive Deafness 111	Deafness, Autosomal Recessive, 111

Deafness, Autosomal Recessive 61

DFNB61	Autosomal Recessive Nonsyndromic Deafness 61
Autosomal Recessive Deafness 61	Deafness, Autosomal Recessive, 61
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 61	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 61
Deafness, Autosomal Recessive, Type 61

Deafness, Autosomal Recessive 8

Neurosensory Nonsyndromic Recessive Deafness 8	DFNB8
Dfnb10	Deafness, Autosomal Recessive 10
Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8	Nsrd8
Autosomal Recessive Nonsyndromic Deafness 8	Deafness, Autosomal Recessive 8/10
Autosomal Recessive Deafness 10	Autosomal Recessive Deafness 8
Childhood-Onset Neurosensory Autosomal Recessive Deafness 8	Nrsd8
Deafness, Autosomal Recessive, 8	Childhood-Onset Neurosensory Deafness Autosomal Recessive 8
Deafness Autosomal Recessive 10	Deafness Autosomal Recessive 8/10
Deafness Neurosensory Autosomal Recessive 8	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8	Deafness, Autosomal Recessive, Type 8/10

Deafness, Autosomal Recessive 28

DFNB28	Autosomal Recessive Nonsyndromic Deafness 28
Autosomal Recessive Deafness 28	Deafness, Autosomal Recessive, 28
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 28	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 28
Deafness, Autosomal Recessive, Type 28

Deafness, Autosomal Dominant 65

DFNA65	Autosomal Dominant Nonsyndromic Deafness 65
Autosomal Dominant Deafness 65	Deafness, Autosomal Dominant, 65
Deafness, Autosomal Dominant, Type 65

Petroclival Meningioma

Deafness, Autosomal Recessive 86

DFNB86	Autosomal Recessive Nonsyndromic Deafness 86
Autosomal Recessive Deafness 86	Deafness, Autosomal Recessive, 86
Deafness, Nonsyndromic, Autosomal Recessive, Type 86

Deafness, Autosomal Dominant 3a

DFNA3A	Autosomal Dominant Nonsyndromic Deafness 3a
Autosomal Dominant Deafness 3a	Deafness, Autosomal Dominant, 3a
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 3a	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 3a
Deafness, Autosomal Dominant, Type 3a

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02837	CLRN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLRN2	VGNC	VGNC:27463
Rattus norvegicus	CLRN2	RGD	RGD:1591112
Mus musculus	CLRN2	MGD	MGI:3646230
Felis catus	CLRN2	VGNC	VGNC:60977
Macaca mulatta	CLRN2	VGNC	VGNC:71380
Canis familiaris	CLRN2	VGNC	VGNC:39360

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