2. Gene
  3. Pim3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

Pim3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 64534 | Gene type: protein coding

About Pim3

Primary_assembly 7: 119,953,175-119,956,587 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 220 orthologues, 2 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 195.9), Heart (RPKM 17.2) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in histone phosphorylation and protein autophosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim3 Products(1)

mRNA Protein Name
NM_022602.1 NP_072124.1 serine/threonine-protein kinase pim-3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9632723 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to forskolin IEP
IEP: Inferred from expression pattern
9632723 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9632723 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pim3 Protein Structure

PKc_like

PKc_like: cl21453 (38 - 292)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-3

kinase induced by depolarization

pim-3 oncogene

protein kinase Kid-1

proviral integration site 3

serine threonine kinase pim3

serine threonine kinase-like

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-101870 Uzansertib Inhibitor / Phase 2
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
HY-19322 PIM447 Inhibitor 99.52% Phase 1
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-123983 HS56 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pim3 NCBI NCBI:415116