CRTC3 - CREB regulated transcription coactivator 3 Gene

Homo sapiens

Also known as TORC3; TORC-3

Gene ID: 64784 | Gene type: protein coding

About CRTC3

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,529,923-90,645,345 (from NCBI)

This gene has 18 transcripts (splice variants), 200 orthologues, 2 paralogues and is associated with 66 phenotypes. Ubiquitous expression in ovary (RPKM 20.6), fat (RPKM 11.8) and 25 other tissues.

Summary

This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate Catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

CRTC3 Products(2)

mRNA	Protein	Name
NM_001042574.3	NP_001036039.1	CREB-regulated transcription coactivator 3 isoform b
NM_022769.5	NP_073606.3	CREB-regulated transcription coactivator 3 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in macrophage activation	IMP IMP: Inferred from mutant phenotype	23033494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRTC3 Protein Structure

TORC_N

TORC_M

TORC_C

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

CREB-regulated transcription coactivator 3

transducer of regulated CREB protein 3

Related Diseases

Diseases

Alias

Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1

Esophageal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma, Esophagus

Salivary Gland Carcinoma

Salivary Gland Cancer	Malignant Neoplasm Of Salivary Gland
Salivary Gland Neoplasms

Lacrimal Gland Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of The Lacrimal Gland

Hidradenoma

Adenoma, Sweat Gland	Hidradenoma Of Skin
Sweat Gland Adenoma	Syringoadenoma
Eccrine Acrospiroma	Benign Neoplasm Of Sweat Gland

Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma	Adenomyo-Epithelioma
Clear Cell Carcinoma	Emc
Epithelial Myoepithelial Carcinoma	Glycogen-Rich Adenocarcinoma
Glycogen-Rich Adenoma	Monomorphic Clear Cell Tumor
Tubular Solid Adenoma	Adenocarcinoma, Clear Cell

Clear Cell Hidradenoma

Clear Cell Myoepithelioma

Eccrine Acrospiroma

Tonsil Cancer

Tonsillar Neoplasms	Malignant Neoplasm Of Faucial Tonsil
Malignant Neoplasm Of Palatine Tonsil	Malignant Neoplasm Of Tonsil, Faucial
Malignant Tonsillar Tumor	Malignant Tumor Of Tonsil
Tonsillar Carcinoma	Malignant Neoplasm Tonsil

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120877	MRT199665		99.74%	Unkown
HY-120877A	(R)-MRT199665		98.70%	Unkown
HY-RS03202	CRTC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CRTC3	VGNC	VGNC:61194
Bos taurus	CRTC3	VGNC	VGNC:27729
Rattus norvegicus	CRTC3	RGD	RGD:1309666
Mus musculus	CRTC3	MGD	MGI:1917711
Canis familiaris	CRTC3	VGNC	VGNC:53163
Macaca mulatta	CRTC3	VGNC	VGNC:71584

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